Case Study: Two Instances of Idiopathic Plasmacytic Lymphadenopathy, a Subtype of Idiopathic Multicentric Castleman Disease, Accompanied by Xanthelasma Palpebrum from a Canadian Institution - Report - MDSpire

Case Study: Two Instances of Idiopathic Plasmacytic Lymphadenopathy, a Subtype of Idiopathic Multicentric Castleman Disease, Accompanied by Xanthelasma Palpebrum from a Canadian Institution

  • By

  • Andrew A. Y. Chen

  • Vivian T. Yin

  • Paula Blanco

  • Mark Trinder

  • Richard I. Crawford

  • Ryan Henrie

  • Stephen Parkin

  • Nasreen Khalil

  • Mollie Carruthers

  • Lu Zhang

  • Luke Y. C. Chen

  • February 23, 2026

  • 0 min

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Clinical Report: Two Instances of Idiopathic Plasmacytic Lymphadenopathy

Overview

{'normolipemic xanthelasma palpebrum': 'Define this term for clarity.'}

Background

{'misdiagnosis implications': 'Add details on clinical consequences of misdiagnosing iMCD-IPL.'}

Data Highlights

{'significance': 'Explain the importance of lacking numerical or trial data.'}

Key Findings

{'terminology': "Use 'xanthelasma' consistently."}

Clinical Implications

{'diagnostic tests': 'Include specific tests for iMCD-IPL.'}

Conclusion

{'future research': 'Highlight the need for research on iMCD-IPL and xanthomas.'}

References

  1. Blood Cancer Journal, 2015 -- Effectiveness of Bortezomib and Thalidomide in Treating Recurrent Multicentric Mixed-Type Castleman's Disease
  2. Blood Cancer Journal, 2022 -- Dermatological Symptoms Associated with Monoclonal Gammopathy
  3. Open Forum Infectious Diseases, 2023 -- A Family's Battle Against Tropheryma whipplei: Insights from a Case Series
  4. International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease | Blood | American Society of Hematology
  5. International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease | Blood | American Society of Hematology
  6. Infection — A Case Study of a 38-Year-Old Female with Necrotizing Cervical Lymphadenitis Induced by Histoplasma capsulatum
  7. Expert Perspective: Diagnosis and Treatment of Castleman Disease - PMC
  8. International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease | Blood | American Society of Hematology
  9. International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease | Blood | American Society of Hematology

Original Source(s)

Case Study: Two Instances of Idiopathic Plasmacytic Lymphadenopathy, a Subtype of Idiopathic Multicentric Castleman Disease, Accompanied by Xanthelasma Palpebrum from a Canadian Institution

  • by Andrew A. Y. Chen, Vivian T. Yin, Paula Blanco, Mark Trinder, Richard I. Crawford, Ryan Henrie, Stephen Parkin, Nasreen Khalil, Mollie Carruthers, Lu Zhang, Luke Y. C. Chen

  • February 23, 2026

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