Uptake and Use of Biologic Therapies in Paediatric Immune-Mediated Inflammatory Diseases: An Australian Population-Based Study - Report - MDSpire

Utilization and Adoption of Biologic Treatments in Pediatric Immune-Mediated Inflammatory Disorders: A Population-Based Analysis from Australia

  • By

  • Jun Ni Ho

  • Jodie Hillen

  • Natasha Nassar

  • Helga Zoega

  • Timothy Beukelman

  • Nicole Pratt

  • Benjamin Daniels

  • July 1, 2026

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Utilization and Adoption of Biologic Treatments in Pediatric IMIDs

Overview

This study analyzes the uptake of biologic treatments for pediatric immune-mediated inflammatory disorders (IMIDs) in Australia, highlighting the characteristics of children receiving these therapies.

Background

Pediatric immune-mediated inflammatory diseases (IMIDs) are increasingly prevalent and significantly affect children's quality of life. Traditional treatments have limitations, leading to a rise in the use of biologic therapies. Understanding the real-world utilization of these treatments is crucial for ensuring safety and effectiveness in the pediatric population.

Data Highlights

No numerical data available in the source material.

Key Findings

  • Ten biologic medicines are approved by the Therapeutic Goods Administration (TGA) for pediatric IMIDs in Australia.
  • Biologic treatments have demonstrated clinical efficacy compared to conventional therapies.
  • Safety data for biologics in pediatric populations are often lacking due to exclusion from clinical trials.
  • Post-market safety studies predominantly focus on adult populations, with limited data on pediatric use.
  • Only one international study has previously examined the use of biologics in pediatric IMIDs.

Clinical Implications

Clinicians should be aware of the limited safety data available for biologic treatments in pediatric populations.

Conclusion

This study provides insights into the utilization of biologic therapies for pediatric IMIDs in Australia.

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  3. Drug Safety, 2025 -- Comprehensive Assessment of Risk Management Strategies for Biologic Therapies in Australia
  4. JAMA Network Open, 2023 -- Population-Level Trends in Asthma Exacerbations After Introduction of Respiratory Biologics
  5. American College of Rheumatology, 2026 -- ACR Releases Updated Juvenile Idiopathic Arthritis Guidelines
  6. ECCO Guidelines on Medical Management of Crohn’s Disease
  7. American Academy of Dermatology Pediatric Atopic Dermatitis Guidelines
  8. ACR Releases Updated Juvenile Idiopathic Arthritis Guidelines | American College of Rheumatology

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