Combination Therapy in Myopia Control - Report - MDSpire
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Combination Therapy in Myopia Control

  • By

  • Jan Roelof Polling

  • Trine Møldrup Jakobsen

  • Leila Sara Eppenberger

  • Andrzej Grzybowski

  • August 14, 2026

  • 9 min

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Clinical Report: Combination Therapy in Myopia Control

Overview

Combination therapy is increasingly considered for myopia control, particularly in children with ongoing progression despite monotherapy. It is essential to identify specific cases where escalation is warranted.

Background

Myopia is a growing concern, particularly in children, as it can lead to significant visual impairment. Clinicians have various treatment options, including atropine and optical interventions, but determining when to escalate treatment remains a challenge. Understanding the risk factors for progression is crucial for effective management.

Data Highlights

No specific numerical data provided in the source material.

Key Findings

  • Combination therapy should be a targeted escalation strategy rather than a default response to progression.
  • Children with rapid axial elongation, high axial length percentiles, or strong family histories may require combination therapy.
  • A structured audit of treatment adherence and measurement consistency is essential before considering combination therapy.
  • Most studies on combination therapy focus on 0.01% atropine with optical interventions like orthokeratology.
  • Combination therapy generally shows better outcomes than monotherapy with 0.01% atropine alone.

Clinical Implications

Clinicians should assess each child's risk factors and treatment adherence before considering combination therapy. A structured audit can help differentiate between true treatment failure and apparent failure due to measurement inconsistencies or poor adherence.

Conclusion

Combination therapy in myopia control should focus on children who exhibit strong progression signals and ensuring that current treatments are appropriately managed.

Related Resources & Content

  1. Contact Lens Spectrum, 2024 -- Combination Therapies for Myopia Control
  2. The Ophthalmologist, 2026 -- Dual Therapy for Myopia Control
  3. Optometric Management, 2023 -- Clinical: Myopia Management
  4. IMI—Interventions for Controlling Myopia Onset and Progression 2025 - PMC
  5. American Association for Pediatric Ophthalmology and Strabismus -- Myopia and Treatment of Myopia in Children
  6. COPH Consensus Guidelines on Childhood Myopia (Final) 2026 0519
  7. optometric management — CLINICAL Myopia Management
  8. IMI—Interventions for Controlling Myopia Onset and Progression 2025 - PMC
  9. MYOPIA AND TREATMENT OF MYOPIA IN CHILDREN - American Association for Pediatric Ophthalmology and Strabismus
  10. COPH Consensus Guidelines on Childhood Myopia (Final) 2026 0519
  11. Combined 0.01% atropine with orthokeratology in childhood myopia control (AOK) study: A 2-year randomized clinical trial - ScienceDirect
  12. https://www.hoyavision.com/globalassets/__regional-assets/global/arvo-2025/villahoz-guemes-et-al.-1y-data-aspect-rct-arvo-2025-abstract.pdf
  13. Interventions to slow the progression of short-sightedness in children | Cochrane

Original Source(s)

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