Prone position ventilation combined with high-flow nasal cannula oxygen therapy in patients with pulmonary infection: a retrospective study on evidence-based nursing practice - Report - MDSpire

Prone position ventilation combined with high-flow nasal cannula oxygen therapy in patients with pulmonary infection: a retrospective study on evidence-based nursing practice

  • By

  • Wenjun Lai

  • Jing Fei

  • Ye Gao

  • Yan He

  • July 6, 2026

  • 0 min

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Clinical Report: Evaluation of Prone Ventilation and High-Flow Nasal Cannula Oxygen Therapy

Overview

This study evaluates the outcomes of prone position ventilation (PPV) combined with high-flow nasal cannula (HFNC) oxygen therapy in patients with pulmonary infections.

Background

Pulmonary infections are a significant cause of acute respiratory failure. Effective respiratory management is essential for recovery, particularly in critically ill patients. The study explores non-invasive strategies like PPV and HFNC.

Data Highlights

OutcomeObservation Group (PPV + HFNC)Control Group (Conventional Therapy)
PaO2/FiO2 Ratio Improvement at 72h48.6 mmHg (95% CI, 41.5 to 55.7)-
SpO2 ImprovementHigher-
Respiratory Rate ReductionGreater-
Total Complications9.0%45.0%
ICU Admission Rate5.0%19.0%
Length of Stay (days)8.7 ± 2.412.0 ± 2.9

Key Findings

  • PPV combined with HFNC showed improvements in PaO2/FiO2 ratio and SpO2 over 72 hours compared to conventional therapy.
  • Nurse-assessed comfort and compliance scores were higher in the observation group.
  • Total complications were lower in the observation group (9.0% vs. 45.0%).
  • ICU admission rates were lower in the observation group (5.0% vs. 19.0%).
  • The length of hospital stay was shorter in the observation group (8.7 ± 2.4 days vs. 12.0 ± 2.9 days).

Clinical Implications

Further research is needed to explore the potential of PPV combined with HFNC in managing pulmonary infections.

Conclusion

PPV combined with HFNC oxygen therapy is associated with certain outcomes compared to conventional oxygen therapy. Further prospective randomized trials are needed to confirm these findings.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- Summary of the best evidence for adult nasal high-flow oxygen therapy nebulization management
  2. Respiratory Care, 2026 -- High-Flow Nasal Cannula in COPD: An Update in Current Evidence
  3. Frontiers in Medicine, 2026 -- High-Flow Nasal Cannula for Acute Respiratory Failure: A Bibliometric Analysis of Current Trends and Future Directions
  4. Surviving Sepsis Campaign Adult Guidelines | SCCM, 2026
  5. New England Journal of Medicine, 2026 -- High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure
  6. BMC Anesthesiology, 2026 -- Awake prone positioning reduces mortality, intubation, and hospital stay in acute hypoxemic respiratory failure: a systematic review and meta-analysis of 6,164 patients
  7. Frontiers in Medicine — Prevention and management of nosocomial infections in patients undergoing extracorporeal membrane oxygenation: a summary of best evidence
  8. Surviving Sepsis Campaign Adult Guidelines | SCCM
  9. High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure | New England Journal of Medicine
  10. Awake prone positioning reduces mortality, intubation, and hospital stay in acute hypoxemic respiratory failure: a systematic review and meta-analysis of 6,164 patients | BMC Anesthesiology | Springer Nature Link

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