Clinical Report: Association Between Triglyceride-Glucose Index and Impaired Nocturnal Oxygenation in Obstructive Sleep Apnea Patients
Overview
This study investigates the relationship between the triglyceride-glucose (TyG) index and nocturnal oxygenation parameters in patients with obstructive sleep apnea (OSA).
Background
Obstructive sleep apnea (OSA) is a prevalent disorder that can lead to significant cardiovascular and metabolic complications. Understanding the relationship between metabolic markers like the TyG index and nocturnal oxygenation can provide insights into the physiological stress experienced by OSA patients.
Data Highlights
Parameter
TyG Index
P-value
Lowest SpO2 <80%
9.252 (8.872, 9.577)
<0.001
Lowest SpO2 ≥80%
8.780 (8.574, 8.963)
AHI ≥30 events/h
9.242 (8.869, 9.624)
<0.001
AHI <30 events/h
8.823 (8.571, 9.121)
Key Findings
TyG index was significantly higher in patients with lowest SpO2 <80% compared to those with lowest SpO2 ≥80%.
TyG index was also higher in patients with AHI ≥30 events/h compared to those with AHI <30 events/h.
TyG positively correlated with AHI and CT90, and negatively with mean and lowest SpO2.
The area under the curve (AUC) for TyG in predicting lowest SpO2 <80% was 0.760.
After adjusting for age, sex, BMI, and monitoring modality, TyG remained associated with lowest SpO2 <80% and AHI ≥30 events/h.
Clinical Implications
The findings indicate an association between the TyG index and nocturnal oxygenation impairment in OSA patients.
Conclusion
Higher TyG index levels are linked to worse nocturnal oxygenation and greater OSA severity.
