Diplopia as the herald of fulminant myocarditis in undifferentiated connective tissue disease: a case report - Report - MDSpire

Diplopia as the herald of fulminant myocarditis in undifferentiated connective tissue disease: a case report

  • By

  • Yongqi Chen

  • Yinping Li

  • Rui Zhang

  • Xiaokang Liu

  • Jingwen Zhang

  • Ning Zhai

  • Hanheng Zuo

  • Xueying Chen

  • June 4, 2026

  • 0 min

Share

Isolated Diplopia as an Initial Indicator of Fulminant Myocarditis

Overview

This report details a rare case of fulminant myocarditis associated with undifferentiated connective tissue disease, initially presenting as isolated diplopia. The patient experienced significant clinical improvement following appropriate immunosuppressive therapy after a complex diagnostic journey.

Background

Undifferentiated connective tissue disease (UCTD) can lead to severe complications such as fulminant myocarditis, which is often underrecognized due to overlapping symptoms with other cardiac conditions. Early diagnosis and treatment are crucial to prevent potentially fatal outcomes. This case emphasizes the importance of considering atypical presentations in the diagnosis of autoimmune myocarditis.

Data Highlights

No numerical data available in the article.

Key Findings

  • Isolated diplopia can be a rare initial manifestation of UCTD-associated fulminant myocarditis.
  • The patient had elevated cardiac enzymes and ECG changes suggestive of myocardial infarction, but coronary angiography showed no stenosis.
  • Endomyocardial biopsy confirmed lymphocytic myocarditis, guiding treatment decisions.
  • Premature tapering of corticosteroids led to relapse, highlighting the need for careful management of immunosuppressive therapy.
  • At three-year follow-up, the patient remained in remission with complete resolution of symptoms.

Clinical Implications

Clinicians should be aware of atypical presentations of myocarditis, such as isolated diplopia, particularly in patients with UCTD. Endomyocardial biopsy is essential for accurate diagnosis and treatment guidance. Careful management of corticosteroid therapy is critical to prevent relapse.

Conclusion

This case underscores the diagnostic challenges of autoimmune myocarditis and the necessity for vigilant monitoring and tailored treatment strategies in patients with UCTD.

Related Resources & Content

  1. Clinical Research in Cardiology, 2009 -- Imaging Techniques for Non-Invasive Diagnosis of Acute Viral Myocarditis
  2. Clinical Research in Cardiology, 2022 -- Cardiac Involvement in a 6-Year-Old Girl with Single Coronary Artery and Severe Multisystem Inflammatory Syndrome Following Asymptomatic SARS-CoV-2 Infection
  3. Clinical Rheumatology, 2022 -- Cardiac Manifestations in Dermatomyositis Associated with Anti-MDA5 Antibodies: A Review of Case Studies
  4. ESC Guidelines, 2025 -- Management of myocarditis and pericarditis
  5. Scientific Reports, 2025 -- Immunosuppressive therapy in patients with biopsy-proven inflammatory myocardial disease: a systematic review and meta-analysis
  6. Clinical Research in Cardiology — Rare instance of cardiac ATTR amyloidosis associated with situs inversus totalis
  7. https://www.escardio.org/static-file/Escardio/Guidelines/Products/Essential%20Messages/2025%20Gls/2025%20Essential%20Messages_MyoPeri.pdf
  8. Immunosuppressive therapy in patients with biopsy-proven inflammatory myocardial disease: a systematic review and meta-analysis | Scientific Reports
  9. Management of inflammatory cardiopulmonary manifestations in systemic lupus erythematosus: a systematic review | Advances in Rheumatology | Springer Nature Link

Original Source(s)

Related Content