Clinical Report: Association of Hemorrhage-Coagulation Immune Phenotype in CRC

Overview

This study identifies a hemorrhage-coagulation immune phenotype (HCIP) in colorectal cancer that correlates with CD163/HO-1-enriched macrophage remodeling and recurrence-free survival (RFS).

Background

Colorectal cancer is a leading cause of cancer-related mortality, and recurrence after surgery poses significant challenges in patient management. Understanding the immune microenvironment, particularly the roles of macrophages and coagulation, is crucial for improving prognostic assessments and therapeutic strategies.

Data Highlights

Key Findings

• HCIP-poor tumors are associated with advanced AJCC stage and larger tumor size.
• These tumors exhibit lower CD8+ T-cell density and higher CD163+ macrophage density.
• HCIP-poor status correlates with worse recurrence-free survival (adjusted HR 1.91).
• Fibrinogen is identified as the most stable marker associated with RFS.
• Inclusion of HCIP and its components provides modest incremental prognostic value beyond clinical variables.

Clinical Implications

The identification of HCIP may assist clinicians in stratifying colorectal cancer patients based on recurrence risk.

Conclusion

The study establishes HCIP as a relevant immune phenotype in colorectal cancer, linking local hemorrhagic pathology and systemic coagulation with recurrence risk.

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