Clinical Report: Coexistence of Multiple Superficial Lipomatous Nevi and a Verrucous Nevus
Overview
This case report describes the rare coexistence of nevus lipomatosus cutaneous superficialis (NLCS) and verrucous epidermal nevus (VEN) in a 20-year-old male. The findings suggest a potential common developmental origin for these hamartomas.
Background
Nevus lipomatosus cutaneous superficialis (NLCS) is a rare benign hamartoma characterized by ectopic mature adipocytes within the dermis, while verrucous epidermal nevus (VEN) is a common epidermal hamartoma presenting with verrucous hyperplasia. The coexistence of these two entities is exceedingly rare, with only a few cases documented, highlighting the need for awareness among clinicians regarding combined hamartomas.
Data Highlights
No numerical data or trial data available in the article.
Key Findings
['The patient presented with multiple skin-colored lesions on the left lower back, measuring approximately 24 × 11 cm.', 'Histopathological examination confirmed the diagnosis of NLCS with mature adipose tissue in lobules within the dermis.', 'Biopsy of a newly developed papule revealed characteristics consistent with VEN, including epidermal papillomatous hyperplasia and hyperkeratosis.', 'The coexistence of NLCS and VEN suggests a possible common developmental origin during embryonic development.', 'Clinicians should consider the possibility of combined hamartomas when encountering linear or zosteriform skin lesions.']
Clinical Implications
This case underscores the importance of considering multiple diagnoses when evaluating skin lesions that present in a linear or zosteriform pattern. Clinicians should perform multiple-site biopsies to ensure accurate diagnosis and avoid underdiagnosis.
Conclusion
The coexistence of NLCS and VEN in this patient highlights the complexity of skin hamartomas and suggests a need for further investigation into their developmental origins.
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