Impact of Prepregnancy Body Mass Index on Macrosomia Risk Following Fresh Embryo Transfer

Overview

This study identifies a significant association between higher prepregnancy BMI and increased risk of macrosomia in singleton pregnancies following fresh embryo transfer.

Background

Obesity is a growing public health concern, particularly affecting reproductive health and outcomes in assisted reproductive technologies like IVF. Elevated prepregnancy BMI has been linked to adverse neonatal outcomes.

Data Highlights

Key Findings

• Higher prepregnancy BMI is positively associated with increased birthweight and Z-score.
• Macrosomia incidence is 2.25-fold higher in women with BMI 25-29.9 kg/m² compared to normal BMI.
• Women with BMI ≥30 kg/m² have a 4.56-fold increased risk of macrosomia.
• A BMI threshold of 26.22 kg/m² is identified, above which the odds of macrosomia significantly increase.
• Propensity score matching analysis confirms higher odds of macrosomia for BMI >26.22 kg/m².

Clinical Implications

The study findings suggest that prepregnancy BMI is associated with neonatal risks for women undergoing IVF.

Conclusion

The study highlights the association between prepregnancy BMI and macrosomia in IVF patients.

Related Resources & Content

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3. Frontiers in Endocrinology, 2026 -- Elevated triglyceride glucose-body mass index is associated with a higher risk of reduced cumulative live birth and adverse pregnancy outcomes in women undergoing assisted reproductive technology: a retrospective cohort study
4. Adult BMI Categories | BMI | CDC
5. The BMJ, 2025 -- Gestational weight gain and risk of adverse maternal and neonatal outcomes in observational data from 1.6 million women: systematic review and meta-analysis
6. Frontiers in Endocrinology — Pre-pregnancy BMI Modifies the Optimal Interpregnancy Interval for Preventing Preterm Birth: A Population-Based Retrospective Cohort Study
7. Adult BMI Categories | BMI | CDC
8. Gestational weight gain and risk of adverse maternal and neonatal outcomes in observational data from 1.6 million women: systematic review and meta-analysis | The BMJ
9. The synergistic effect of transfer of blastocyst and embryo vitrification on birthweight: a retrospective cohort study - ScienceDirect