Radiomic Heterogeneity of ASL Perfusion Correlates with Early Mortality in IDH-Wildtype Glioblastoma

Overview

This study investigates the relationship between ASL perfusion heterogeneity and early mortality in patients with IDH-wildtype glioblastoma.

Background

Glioblastoma is the most aggressive primary brain tumor, with a poor prognosis and limited survival rates. This study aims to clarify the relationship between ASL radiomics and early mortality.

Data Highlights

The study analyzed a cohort of 322 patients with IDH-wildtype glioblastoma, focusing on the relationship between ASL radiomic features and early mortality.

Key Findings

• Greater ASL heterogeneity was associated with increased mortality within 365 days (HR 1.39, p=0.015).
• The association persisted after adjusting for tumor volume and clinical variables.
• Machine-learning classification did not show incremental value of ASL radiomics beyond a volume-aware clinical baseline.
• DTI-ALPS did not enhance classifier performance or show an independent association with survival.
• The effect of ASL heterogeneity on mortality was most pronounced within the first 180 days post-imaging.

Clinical Implications

The findings indicate the association of ASL perfusion heterogeneity with early mortality in glioblastoma patients, but the influence of tumor volume on overall survival necessitates careful volume-adjusted analyses.

Conclusion

ASL perfusion heterogeneity correlates with early mortality in IDH-wildtype glioblastoma, but its prognostic value is limited when accounting for tumor volume.

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