Effects of different exercise interventions on quality of life in breast cancer survivors after treatment: a systematic review and network meta-analysis - Report - MDSpire

Effects of different exercise interventions on quality of life in breast cancer survivors after treatment: a systematic review and network meta-analysis

  • By

  • Xiangyu Zhao

  • Yuanxing Wang

  • Yanbo Yi

  • Haitao Zhan

  • Hao Chen

  • Qiao Song

  • April 30, 2026

  • 0 min

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Clinical Report: Impact of Exercise on Quality of Life Among Breast Cancer Survivors

Overview

This systematic review and network meta-analysis evaluated the effects of various exercise modalities on quality of life (QoL) among breast cancer survivors, specifically focusing on randomized controlled trials (RCTs). The findings indicate that combined exercise is the most effective modality for improving QoL, with significant benefits observed across multiple exercise types.

Background

With over 7.8 million breast cancer survivors globally, optimizing QoL post-treatment is crucial. Survivors often face persistent health challenges that diminish their QoL, necessitating effective rehabilitation strategies. Exercise has emerged as a key non-pharmacological intervention to address these multifaceted challenges.

Data Highlights

Exercise ModalitySMD95% CISUCRA
Combined Exercise1.400.95–1.8695.4%
Tai Chi0.980.60–1.3671.5%
Aerobic Exercise0.790.45–1.1363.4%
Qigong0.770.42–1.1260.1%
Yoga0.580.25–0.9145.4%
Resistance Training0.540.20–0.8842.1%

Key Findings

  • Combined exercise significantly improves QoL compared to usual care.
  • Tai Chi and aerobic exercise also show notable benefits for QoL.
  • High-intensity interval training and Pilates did not demonstrate significant improvements.
  • Exercise interventions can address both physical and psychological sequelae in breast cancer survivors.
  • Personalized exercise prescriptions are supported by modality-specific evidence.

Clinical Implications

Healthcare providers should consider integrating combined exercise programs into survivorship care plans for breast cancer survivors. Tailoring exercise modalities to individual patient needs, based on evidence, can enhance QoL and address specific health challenges faced by this population.

Conclusion

The findings underscore the importance of exercise in improving QoL among breast cancer survivors, highlighting the need for personalized exercise interventions in survivorship care based on the evidence presented.

References

  1. The ASCO Post, 2023 -- Exercise May Boost Quality of Life for Patients With Metastatic Breast Cancer
  2. The ASCO Post, 2024 -- Effect of Exercise on Symptom Burden and Quality of Life in Patients With Metastatic Breast Cancer
  3. The ASCO Post, 2025 -- Exercise Training Improves Strength and Quality of Life for Patients With Metastatic Breast Cancer
  4. NCCN Guidelines® Insights - Survivorship, Version 2.2025
  5. Effect of physical exercise on the quality of life of women surviving breast cancer: systematic review with meta-analysis of randomized clinical trials
  6. The ASCO Post — Patients With Advanced Breast Cancer May Gain Multiple Benefits From Exercise as Part of Palliative Care Related Articles
  7. NCCN Guidelines® Insights - Survivorship, Version 2.2025 | NCCN Continuing Education
  8. Effect of physical exercise on the quality of life of women surviving breast cancer: systematic review with meta-analysis of randomized clinical trials - ScienceDirect
  9. Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer - PMC

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