Clinical Report: Essential Oxidative Phosphorylation-Associated Genes in Burn Injuries

Overview

This study identifies 23 oxidative phosphorylation-related genes as potential biomarkers for immune response in burn injuries. Three core genes, ATP6V1C1, ECHS1, and LDHA, were validated for their roles in immune modulation.

Background

Burn injuries are a major global health issue, leading to severe trauma and significant systemic inflammatory responses. The identification of reliable biomarkers for early diagnosis and assessment of burn severity is critical.

Data Highlights

Key Findings

• Identification of 23 differentially expressed oxidative phosphorylation-related genes in burn patients.
• Core genes ATP6V1C1, ECHS1, and LDHA are associated with burn progression.
• Group A patients showed heightened immune activity compared to Group B patients.
• Knockdown of ATP6V1C1 or LDHA reduced pro-inflammatory cytokine secretion.
• A diagnostic nomogram based on core genes demonstrated diagnostic capability.

Clinical Implications

The identified core genes may serve as potential molecular targets for enhancing prognosis in burn patients.

Conclusion

This study highlights oxidative phosphorylation-associated genes as biomarkers for immune response in burn injuries.

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