A case report of synchronous bilateral breast cancer with distinct histological subtypes and favorable long-term survival - Report - MDSpire

A case report of synchronous bilateral breast cancer with distinct histological subtypes and favorable long-term survival

  • By

  • PingBo Zhang

  • DaWei Zhao

  • June 12, 2026

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Clinical Report: Synchronous Bilateral Breast Cancer with Different Histologies

Overview

This report details a case of synchronous bilateral breast cancer in a 51-year-old woman, revealing two distinct histological types: invasive breast carcinoma with apocrine differentiation and multifocal mucinous carcinoma.

Background

Synchronous bilateral breast cancer is a rare occurrence, representing 1%–5% of all breast cancer cases, and presents unique challenges in diagnosis and treatment. The presence of different pathological and molecular subtypes complicates clinical management.

Data Highlights

No numerical data or trial data presented in the article.

Key Findings

  • A 51-year-old woman was diagnosed with synchronous bilateral breast cancer.
  • The right breast lesion was identified as invasive breast carcinoma with apocrine differentiation, while the left breast contained multifocal mucinous carcinoma.
  • Intraoperative frozen pathology confirmed bilateral malignancy, leading to a bilateral mastectomy.
  • The patient received a comprehensive treatment regimen including TAC chemotherapy and capecitabine maintenance therapy.
  • At 31 months postoperatively, the patient remained disease-free with no signs of recurrence.

Clinical Implications

This case illustrates the necessity for thorough imaging and pathological evaluations in patients with synchronous bilateral breast cancer.

Conclusion

This case report highlights the management of a patient with synchronous bilateral breast cancer exhibiting distinct histological types.

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  5. NCCN Guidelines® Insights: Breast Cancer, Version 5.2025 -- https://pubmed.ncbi.nlm.nih.gov/41213254/?utm_source=openai
  6. Frontiers in Oncology — Synchronous lung adenocarcinoma in situ and type B2-B3 thymoma in a frozen hemithorax: a case report and multidisciplinary approach
  7. Hypofractionated and conventionally fractionated radiotherapy for synchronous bilateral breast cancer: clinical and dosimetric outcomes | Strahlentherapie und Onkologie | Springer Nature Link
  8. NCCN Guidelines® Insights: Breast Cancer, Version 5.2025 - PubMed

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