Clinical Report: Acquired Reactive Perforating Collagenosis in a Patient

Background

Acquired reactive perforating collagenosis is a rare dermatologic condition often associated with systemic diseases such as diabetes mellitus and chronic kidney disease. It is characterized by the transepidermal elimination of collagen, leading to pruritic skin lesions.

Data Highlights

No numerical or trial data provided in the source material.

Key Findings

• A 55-year-old male with ARPC presented with multiple systemic comorbidities including type 2 diabetes and chronic renal failure.
• Histopathological examination revealed cup-shaped epidermal invaginations with necrotic debris and transepidermal extrusion of modified collagen.
• The patient experienced minimal improvement in pruritus after one month of treatment.
• ARPC is often associated with systemic diseases, necessitating a comprehensive clinical assessment.

Clinical Implications

Clinicians should consider ARPC in the differential diagnosis of pruritic skin lesions, particularly in patients with diabetes and chronic kidney disease. Comprehensive evaluation of underlying systemic conditions is essential for effective management.

Conclusion

Acquired reactive perforating collagenosis is a rare condition that can coexist with significant systemic health issues.

Related Resources & Content

1. Frontiers in Medicine, 2026 -- Tracing the clinicodermoscopic and histopathological evolution of acquired reactive perforating collagenosis: a case report
2. Acquired Perforating Dermatosis - StatPearls - NCBI Bookshelf
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6. Acquired Reactive Perforating Collagenosis—A Rare Entity Occurring Within Common Disorders: A Systematic Review and Our Personal Experience
7. Acquired Perforating Dermatosis - StatPearls - NCBI Bookshelf
8. https://www.dermatol.or.jp/uploads/uploads/files/guideline/perforating_dermatosis.pdf