A pilot randomized controlled trial of a multicomponent intervention to improve sexual function in female breast cancer survivors - Report - MDSpire
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A preliminary randomized controlled study of a comprehensive intervention aimed at enhancing sexual function in women who have survived breast cancer

  • By

  • Noël M. Arring

  • Carolyn Lafferty

  • Jeanne Carter

  • Deborah Marshall

  • Jennifer Barsky Reese

  • September 9, 2026

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Clinical Report: A preliminary randomized controlled study of a comprehensive intervention aimed at enhancing sexual function in women who have survived breast cancer

Overview

This pilot randomized controlled trial assessed the feasibility of a combined hypnotic relaxation intervention and vaginal moisturizer for improving sexual function and body image in female breast cancer survivors. Results indicated improvements in sexual desire, body image, and genitourinary syndrome of menopause (GSM) symptoms, though specific significance levels were not detailed.

Background

Sexual health issues are prevalent among breast cancer survivors, affecting 30%–80% of this population, according to various studies. These challenges often include symptoms of genitourinary syndrome of menopause (GSM) and psychological factors such as negative body image. Addressing these concerns is crucial for improving overall quality of life in this demographic.

Data Highlights

OutcomeEffect Size (d)
FSFI lubrication1.50 (0.97, 2.02)
Pain0.81 (0.39, 1.22)
SexFS V2 interest0.37
Body image0.42

Key Findings

  • Thirty participants were randomized to either the hypnotic relaxation intervention (HRI) or vaginal moisturizer alone (VMO).
  • Study completion was achieved by all participants, with adherence rates of 92% for HRI and 90% for VMO.
  • Improvements in sexual desire, body image, and GSM-related outcomes were observed in both groups, with change-score effects favoring HRI over VMO for sexual interest and body image.
  • FSFI lubrication showed a large effect size, indicating improvement.

Clinical Implications

The findings indicate that a combined approach of hypnotic relaxation and vaginal moisturizer may address sexual health issues in breast cancer survivors.

Conclusion

This study demonstrates the feasibility of a combined intervention for enhancing sexual function and body image among breast cancer survivors, warranting further investigation in larger trials.

Related Resources & Content

  1. Huynh et al, Annals of Surgical Oncology, 2022 -- Study Could Lead to Better Education and Treatment of Sexual Health for Patients With Breast Cancer
  2. James Taylor, MD, MPH, The ASCO Post, 2021 -- Overcoming Gender Disparity in Evaluating Sexual Health Following a Cancer Diagnosis
  3. Stern et al, Plastic and Reconstructive Surgery, 2025 -- Breast-Conserving Surgery Linked to Improved Sexual Well-Being Compared With Postmastectomy Breast Reconstruction
  4. Reese et al, Cancer, 2025 -- Efficacy of a couple‐based intervention addressing sexual concerns for breast cancer survivors: Results of a randomized controlled trial
  5. The ASCO Post — Preserving Sexual Function in Women Treated for Cancer
  6. Scope of the problem and contributors in breast cancer survivors
  7. Current guideline and consensus positions (past 12 months)
  8. Pilot randomized control trial of multi-component intervention to improve sexual function in female breast cancer survivors

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