Clinical Features and Factors Associated with Extended Hospital Stays in Cases of Cosmetic Botulinum Toxin Poisoning

Overview

This study analyzes 145 patients hospitalized for cosmetic botulinum toxin poisoning, identifying key clinical features and factors associated with prolonged hospital stays. Dysphagia, slurred speech, and the duration of antitoxin therapy were found to be significant predictors of extended hospitalization.

Background

The rise in cosmetic botulinum toxin use has led to increased incidents of poisoning due to improper administration. This study aims to fill the gap in knowledge regarding inpatient characteristics and risk factors associated with cosmetic botulinum toxin poisoning.

Data Highlights

Key Findings

• The study included 145 patients with a median age of 37 years, predominantly female (97.93%).
• Common injection sites were the forehead (26.35%), periocular region (16.77%), and jaw (11.98%).
• Frequent clinical manifestations included dizziness (89.66%), dysphagia (85.52%), and blurred vision (75.17%).
• Dysphagia, slurred speech, and duration of antitoxin therapy were independently associated with prolonged hospitalization.
• No in-hospital deaths were reported among the patients studied.

Clinical Implications

The findings highlight the importance of monitoring specific symptoms such as dysphagia and slurred speech in patients with cosmetic botulinum toxin poisoning.

Conclusion

Cosmetic botulinum toxin poisoning presents significant clinical challenges, particularly with cranial nerve-related symptoms. Identifying factors associated with prolonged hospitalization can enhance understanding of patient care.

Related Resources & Content

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2. Springer, 2022 -- Efficacy of Botulinum Toxin Injections in Managing Chronic Anal Fissures
3. Springer, 2024 -- Evaluation of Outlet Type Constipation in Adults Following Treatment with Type A Botulinum Toxin
4. CDC -- Clinical Overview of Botulism
5. CDC -- Health Alert Network (HAN) - 00507
6. Infection — Characteristics of Clinical and Microbiological Aspects in Blood Culture Positivity Due to Non-Fermenting Gram-Negative Bacilli Excluding Pseudomonas and Acinetobacter Species (2020–2023)
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8. Health Alert Network (HAN) - 00507 | Adverse Effects Linked to Counterfeit or Mishandled Botulinum Toxin Injections
9. Safety and Clinical Outcomes of an Equine-derived Heptavalent Botulinum Antitoxin Treatment for Confirmed or Suspected Botulism in the United States | Clinical Infectious Diseases | Oxford Academic