The Ratio of Creatinine to Body Weight as a Predictor of Mortality in Critically Ill Heart Failure Patients: Insights from a Retrospective Analysis of the MIMIC-IV Database - Report - MDSpire

The Ratio of Creatinine to Body Weight as a Predictor of Mortality in Critically Ill Heart Failure Patients: Insights from a Retrospective Analysis of the MIMIC-IV Database

  • By

  • Dunlin Fang

  • Yanyi Huang

  • Jian Huang

  • Wanchun Hu

  • Changchang Zhang

  • Xing Liu

  • Zhenyu Shi

  • January 20, 2026

  • 0 min

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Clinical Report: Creatinine-to-Body Weight Ratio and Mortality in Heart Failure

Overview

This study investigates the prognostic value of the creatinine-to-body weight ratio (CWR) in critically ill heart failure (HF) patients using data from the MIMIC-IV database. Findings suggest that CWR may serve as a significant predictor of mortality in this high-risk population.

Background

Heart failure is a leading cause of hospitalization and mortality, particularly in critically ill patients. The rising prevalence of heart failure, coupled with its associated healthcare costs, underscores the need for effective prognostic tools. The creatinine-to-body weight ratio is a potentially valuable metric that may reflect both renal function and overall health status in these patients.

Data Highlights

No specific numerical data provided in the article.

Key Findings

  • The creatinine-to-body weight ratio (CWR) is correlated with mortality in critically ill heart failure patients.
  • Elevated CWR may indicate low body fat and reduced energy reserves, increasing mortality risk.
  • Heart failure patients exhibit higher mortality rates compared to stable counterparts, emphasizing the need for reliable prognostic tools.
  • Creatinine levels are influenced by both cardiac and renal function, complicating their interpretation in critically ill patients.
  • Existing studies suggest that muscle mass is a critical determinant of outcomes in ICU patients.

Clinical Implications

Clinicians should consider the creatinine-to-body weight ratio as a potential prognostic tool in critically ill heart failure patients. Understanding the implications of CWR may aid in risk stratification and management of these patients.

Conclusion

The creatinine-to-body weight ratio appears to be a promising predictor of mortality in critically ill heart failure patients, warranting further investigation to validate its clinical utility.

References

  1. Huang et al., MIMIC-IV Database, 2025 -- The Ratio of Creatinine to Body Weight as a Predictor of Mortality in Critically Ill Heart Failure Patients
  2. Intensive Care Medicine, 2018 -- The Relationship Between Urinary Creatinine Excretion and Mortality Outcomes in Critically Ill Patients
  3. Intensive Care Medicine, 2025 -- The creatinine conundrum in heart failure: rethinking AKI definitions
  4. Critical Care (Springer), 2026 -- Ask not for whom the bell tolls: a meditation on the utility of serum creatinine on Critical Care
  5. Kidney injury in patients with heart failure-related cardiogenic shock: Results from an international, multicentre cohort study - PubMed
  6. KDIGO executive conclusions, 2024 -- KDIGO 2024 CKD Guideline Executive Summary
  7. Clinical Research in Cardiology — Utilizing the Echocardiographic Killip Score to Forecast Hospital Readmissions and Mortality in Heart Failure Patients
  8. Kidney injury in patients with heart failure-related cardiogenic shock: Results from an international, multicentre cohort study - PubMed
  9. KDIGO executive conclusions
  10. MIMIC-IV v2.2

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