Clinical Report: Evaluation of the Relationship Between SIRT1 Gene Variants and CAD

Overview

This systematic review and meta-analysis assessed the association between SIRT1 gene polymorphisms and coronary artery disease (CAD) risk. The findings indicate that certain SIRT1 variants may be linked to CAD susceptibility.

Background

Coronary artery disease (CAD) is a leading cause of morbidity and mortality globally, influenced by both traditional risk factors and genetic components.

Data Highlights

Key Findings

• Three SIRT1 polymorphisms were evaluated: rs7069102, rs7895833, and rs4746720.
• Rs7069102 showed no significant association with CAD susceptibility across all genetic models.
• Rs7895833 was associated with increased CAD susceptibility only under the recessive model.
• Rs4746720 demonstrated significant associations under both the dominant and heterozygote models.
• Overall methodological quality of included studies ranged from moderate to high.
• Findings should be interpreted cautiously due to the lack of adjustment for major cardiovascular risk factors.

Clinical Implications

The associations between SIRT1 gene variants and CAD susceptibility highlight the potential role of genetic factors in cardiovascular disease. However, the variability in findings necessitates further research with appropriate adjustments for confounding factors.

Conclusion

The evidence suggests that certain SIRT1 polymorphisms may be linked to CAD risk.

Related Resources & Content

1. Frontiers | Association between SIRT1 Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-analysis
2. Clinical Research in Cardiology (Springer) — The prognostic value of systemic inflammatory response index (SIRI) in acute coronary syndrome patients treated with primary percutaneous coronary intervention: a meta-analysis and systematic review
3. Frontiers in Cardiovascular Medicine — Association of systemic inflammation response index and triglyceride-glucose index with the severity of coronary artery stenosis in elderly patients: a retrospective cross-sectional study
4. The Journal of Clinical Endocrinology & Metabolism — Association of Low C-Reactive Protein Variants in HNF1A with Elevated Cardiovascular Disease Risk
5. Basic Research in Cardiology — The Promising Functions of Sirtuins in the Context of Heart Failure
6. 2026 Guideline on the Management of Dyslipidemia - Professional Heart Daily | American Heart Association
7. Coronary Artery Calcium and Polygenic Risk Scores For Cardiovascular Risk Prediction: Results From Two Population-Based Studies - American College of Cardiology
8. Frontiers | Association between SIRT1 Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-analysis