Intravenous leiomyomatosis manifesting as a cardiac mass: a case report - Report - MDSpire

Intravenous leiomyomatosis manifesting as a cardiac mass: a case report

  • By

  • Haoxuan Deng

  • Qiyue Zhu

  • Wei Qiu

  • Yunyan Zhang

  • Junyi Hua

  • June 2, 2026

  • 0 min

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Clinical Report: Intravenous Leiomyomatosis Presenting as a Cardiac Tumor

Overview

This report details a case of intravenous leiomyomatosis (IVL) in a 45-year-old woman presenting with chest tightness, initially misdiagnosed as a cardiac mass. Multimodal imaging confirmed IVL extending from pelvic veins to the right atrium, highlighting the importance of accurate diagnosis and treatment.

Background

Intravenous leiomyomatosis is a rare benign smooth muscle tumor that predominantly affects middle-aged women. Its presentation as a cardiac mass is particularly uncommon, often leading to misdiagnosis and inappropriate treatment. Understanding IVL's clinical and imaging characteristics is crucial for timely and effective management.

Data Highlights

No numerical data or trial data available in the source material.

Key Findings

  • The patient presented with chest tightness and cough, with a history of irregular menstruation.
  • Transthoracic echocardiography revealed a mass in the right atrium, initially suggestive of atrial myxoma.
  • Histopathological examination confirmed the diagnosis of IVL with specific immunohistochemical markers.
  • Multidisciplinary surgical resection was performed, emphasizing the need for coordinated care in such cases.
  • Short-term postoperative imaging data are available, with long-term follow-up ongoing.

Clinical Implications

This case underscores the need for healthcare professionals to consider IVL in the differential diagnosis of cardiac masses, particularly in middle-aged women. Accurate imaging and histopathological evaluation are essential for appropriate management and to avoid misdiagnosis.

Conclusion

Intravenous leiomyomatosis can present as a cardiac mass, necessitating careful diagnostic evaluation to ensure timely surgical intervention. Continued follow-up is important due to the potential for recurrence.

Related Resources & Content

  1. Frontiers in Cardiovascular Medicine, 2026 -- Thoracoscopically assisted resection of left ventricular myxoma: a case report
  2. Clinical Research in Cardiology, 2023 -- Combination of Cadonilimab and Anlotinib Shows Promise in Treating Rare Cardiac Angiosarcoma with Multiple Metastases: A Case Study and Review of Existing Literature
  3. Frontiers in Cardiovascular Medicine, 2026 -- Successful Surgical Treatment of a Giant Right Ventricular Myxoma with Pulmonary Artery Tumor Thrombus in an Adolescent Patient: Case Report
  4. Journal of Gastrointestinal Surgery -- Surgical Approach to Retroperitoneal Leiomyosarcoma Originating from the Inferior Vena Cava
  5. A complex clinical case of intracardiac leiomyomatosis | BMC Cardiovascular Disorders | Full Text
  6. Intravenous leiomyomatosis: A case report and narrative literature review - PubMed
  7. Diagnosis, treatment and clinical outcomes of extrauterine sites of leiomyomatosis: a systematic review - PubMed
  8. A complex clinical case of intracardiac leiomyomatosis | BMC Cardiovascular Disorders | Full Text
  9. Intravenous leiomyomatosis: A case report and narrative literature review - PubMed
  10. Diagnosis, treatment and clinical outcomes of extrauterine sites of leiomyomatosis: a systematic review - PubMed

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