Clinical Report: Breast Involvement in Rosai-Dorfman Disease

Background

Rosai-Dorfman Disease is a rare nonmalignant condition characterized by the accumulation of histiocytes, primarily affecting lymph nodes. Extranodal involvement, particularly in the breast, is uncommon and presents diagnostic challenges. Breast RDD typically presents as a painless palpable mass, often in the subcutaneous layer, and accurate diagnosis may require immunohistochemistry.

Data Highlights

No numerical data available in the article.

Key Findings

• Breast RDD typically presents as a painless palpable mass, often in the subcutaneous layer.
• Extranodal involvement occurs in approximately 43% of RDD cases.
• Breast RDD is more frequently reported in women over 50 years of age.
• Diagnostic challenges include differentiating RDD from malignant lesions, necessitating immunohistochemistry for accurate diagnosis.
• Pathological examination confirmed the diagnosis of extranodal RDD in the reported case.

Clinical Implications

Clinicians should be aware of the potential for breast involvement in RDD, particularly in older women. Accurate diagnosis may require imaging and immunohistochemical analysis.

Conclusion

This case report highlights the rarity of breast involvement in Rosai-Dorfman Disease and the importance of thorough diagnostic evaluation.

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