Clinical Report: Delivery Reveals Brugada Syndrome in a 32-Year-Old Primigravida
Overview
This case study describes a 32-year-old primigravida who developed ventricular fibrillation shortly after an uncomplicated vaginal delivery, revealing a spontaneous type 1 Brugada syndrome pattern.
Background
Brugada syndrome (BrS) is a hereditary cardiac channelopathy that can lead to malignant ventricular arrhythmias and sudden cardiac death, often in individuals with structurally normal hearts. The condition is more prevalent in males, with a reported prevalence of 8–10-fold higher than in females. It can remain asymptomatic until unmasked by various triggers, including pregnancy. Understanding the implications of BrS during the peripartum period is crucial for managing potential cardiac events in pregnant women.
Data Highlights
No numerical or trial data provided in the article.
Key Findings
A 32-year-old primigravida experienced ventricular fibrillation shortly after vaginal delivery.
Baseline ECG was normal, and there was no family history of sudden cardiac death.
Post-resuscitation ECG revealed a spontaneous type 1 Brugada pattern with coved ST-segment elevation.
Laboratory tests indicated borderline hypokalemia and mild hypomagnesemia.
Clinical whole-exome sequencing found no pathogenic variants in arrhythmia-associated genes.
An implantable cardioverter-defibrillator was placed for secondary prevention following the event.
Clinical Implications
Clinicians should consider the potential for unmasking latent channelopathies due to physiological changes and interventions during labor.
Conclusion
The case illustrates the importance of monitoring for arrhythmias in asymptomatic patients.
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