Factors Associated with Cough Improvement After Endoscopic Therapy in GERD Patients

Overview

This study identifies key factors influencing cough resolution in GERD patients post-endoscopic minimally invasive treatment. A predictive model based on these factors demonstrates strong efficacy in forecasting treatment outcomes.

Background

Gastroesophageal reflux disease (GERD) is a prevalent condition that can lead to chronic cough, complicating patient management. Accurate identification of factors that predict cough relief after endoscopic therapy is essential for optimizing treatment strategies and improving patient outcomes. This study addresses a significant gap in understanding the predictors of cough resolution in GERD patients undergoing such interventions.

Data Highlights

Key Findings

• Seven common risk factors for persistent cough identified: age, cough duration, ineffective esophageal motility, DeMeester score, pepsin, FeNO, and SIgA.
• Ineffective esophageal motility and cough duration were significant risk factors for persistent cough (OR = 27.090 and 2.639, respectively).
• SIgA was identified as a protective factor against persistent cough (OR = 0.891).
• The predictive model demonstrated a ROC-AUC of 0.967, indicating excellent discriminatory power.
• Good model calibration was confirmed by the Hosmer-Lemeshow test (P = 0.992).

Clinical Implications

Clinicians should consider the identified risk factors when evaluating GERD patients for endoscopic minimally invasive therapy. The predictive model can guide patient selection and inform treatment decisions to enhance cough resolution outcomes.

Conclusion

The study successfully identifies independent risk factors for persistent cough in GERD patients post-treatment and establishes a predictive model that can aid in clinical decision-making.

Related Resources & Content

1. Ahmed Z et al., Gastroenterology, 2024 -- Factors Associated with Cough Improvement After Endoscopic Minimally Invasive Therapy in GERD Patients with Chronic Cough
2. the new gastroenterologist — Sequential endoscopy may boost GERD control
3. Obesity Surgery — Criteria for Diagnosing Gastro-esophageal Reflux After Sleeve Gastrectomy
4. Surgical Endoscopy — Meta-analysis reveals that fundoplication markedly enhances both objective and subjective outcomes in reflux management
5. The New Gastroenterologist — Comprehensive Approaches to Managing Gastroesophageal Reflux Disease: Medical, Endoscopic, and Surgical Strategies
6. Diagnosis and management of extraesophageal gastroesophageal reflux disease (GERD) - American Gastroenterological Association
7. Effectiveness of transoral endoscopic fundoplication with or without hiatal hernia repair in patients with gerd and chronic cough - PubMed