Physical activity is associated with improved glycemic control but not with IL-6–glycemic interactions in type 2 diabetes: a cross-sectional study - Report - MDSpire
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Physical activity is associated with improved glycemic control but not with IL-6–glycemic interactions in type 2 diabetes: a cross-sectional study
Clinical Report: The Relationship Between Physical Activity and Glycemic Control in Type 2 Diabetes
Overview
This study investigates the associations of physical activity and circulating IL-6 with glycemic control in individuals with type 2 diabetes mellitus (T2DM).
Background
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and low-grade systemic inflammation. This study aims to clarify the relationship between physical activity, IL-6, and metabolic outcomes in T2DM patients.
Data Highlights
The study included 185 participants with T2DM, comparing active (n=98) and sedentary (n=87) individuals. Key findings include:
Key Findings
Physical activity was associated with significantly lower HbA1c, fasting glucose, HOMA-IR, and fructosamine levels.
No significant difference in circulating IL-6 levels was observed between active and sedentary participants.
IL-6 showed inverse correlations with glycemic markers in active individuals but not in sedentary participants.
In multivariable models, IL-6 was not independently associated with glycemic outcomes.
No significant IL-6 × activity interaction effects were observed.
Clinical Implications
The findings indicate that physical activity improves glycemic control in T2DM, while IL-6 does not play a significant independent role.
Conclusion
This study examines the relationship between physical activity and glycemic control in T2DM, while questioning the role of IL-6 as an independent metabolic marker.
by Marwan Ismail, Mutaz Ibrahim Hassan, Amged Gaffer Mostafa, Ashgan A. Ahmed, Sara Mohammed Ali, Ellen Safadi, Ramprasad Muthukrishnan, Praveen Kumar Kandakurti, Asim Ahmed Elnour, Husham O. Elzein, Elryah I. Ali, Velilyaeva Alie Sabrievna, Ayman H. Alfeel
