CXCL10 rs8878 identifies a genotype-associated immune phenotype linked to T-lymphocyte preservation and survival in sepsis - Report - MDSpire

CXCL10 rs8878 as a Genetic Marker for Immune Phenotypes Associated with T-Lymphocyte Maintenance and Survival in Sepsis

  • By

  • Birte Dyck

  • Andrea Witowski

  • Thilo Bracht

  • Malte Bayer

  • Patrick Thon

  • Dominik Ziehe

  • Tim Rahmel

  • Matthias Unterberg

  • Britta Westhus

  • Lars Palmowski

  • Hartmuth Nowak

  • Stefan Felix Ehrentraut

  • Jennifer Orlowski

  • Alexander von Busch

  • Alexander Zarbock

  • Nina Babel

  • Moritz Anft

  • Dietrich Henzler

  • Michael Adamzik

  • Lars Bergmann

  • Barbara Sitek

  • Björn Koos

  • Katharina Rump

  • July 17, 2026

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CXCL10 rs8878 as a Genetic Marker for Immune Phenotypes in Sepsis

Overview

The study identifies the CXCL10 rs8878 genotype as a significant factor influencing T cell dynamics and 30-day survival in septic patients. Carriers of the AA genotype demonstrated higher T cell counts compared to G-allele carriers.

Background

Sepsis is a critical condition characterized by a dysregulated immune response to infection, leading to high morbidity and mortality. T lymphocytes play a crucial role in immune response, and their dysregulation during sepsis is linked to poor clinical outcomes. Understanding genetic factors influencing T cell behavior may provide insights into patient stratification and therapeutic targets.

Data Highlights

GenotypeT Cell Counts30-Day Survival
AAHigherImproved
G-alleleLowerWorse

Key Findings

  • Variants in the CXCL10 gene are associated with T cell dysregulation in sepsis.
  • AA genotype carriers exhibited higher circulating T cell counts compared to G-allele carriers.
  • Higher total and CD8+ T cell counts correlated with improved survival rates.
  • Increased CXCL10 mRNA expression was observed in AA-genotype carriers among non-survivors.
  • CXCL10 concentrations on day 1 were positively correlated with inflammatory cytokines and inversely correlated with total T cell counts.

Clinical Implications

Understanding the genetic influences on T cell dynamics could provide insights into patient stratification.

Conclusion

The CXCL10 rs8878 genotype is linked to T cell maintenance and survival outcomes in sepsis.

Related Resources & Content

  1. Blood Cancer Journal, 2022 -- Functional Assessment and Validation of GWAS-Identified Genetic Variants Linked to Chronic Lymphocytic Leukemia: Insights from the CRuCIAL Study
  2. Intensive Care Medicine, 2022 -- EASIX Levels Prior to Transplantation and Subsequent Sepsis Following Allogeneic Stem Cell Transplantation
  3. Clinical Rheumatology, 2020 -- Reduced IKBKE Expression in Patients with Systemic Lupus Erythematosus
  4. Intensive Care Medicine, 2025 -- Subphenotypes of Sepsis, Theragnostic Approaches, and Tailored Management Strategies
  5. Intensive Care Medicine, 2026 -- Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026
  6. Annals of Intensive Care, 2023 -- Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial
  7. Critical Care: Sepsis and Severe Infection, 2026 -- Beyond the sepsis label: heterogeneity, subphenotypes, and the path to precision therapy
  8. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026 | Intensive Care Medicine | Springer Nature Link
  9. Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial | Annals of Intensive Care | Springer Nature Link
  10. Beyond the sepsis label: heterogeneity, subphenotypes, and the path to precision therapy | Critical Care: Sepsis and Severe Infection | Springer Nature Link

Original Source(s)

CXCL10 rs8878 identifies a genotype-associated immune phenotype linked to T-lymphocyte preservation and survival in sepsis

  • by Birte Dyck, Andrea Witowski, Thilo Bracht, Malte Bayer, Patrick Thon, Dominik Ziehe, Tim Rahmel, Matthias Unterberg, Britta Westhus, Lars Palmowski, Hartmuth Nowak, Stefan Felix Ehrentraut, Jennifer Orlowski, Alexander von Busch, Alexander Zarbock, Nina Babel, Moritz Anft, Dietrich Henzler, Michael Adamzik, Lars Bergmann, Barbara Sitek, Björn Koos, Katharina Rump

  • July 17, 2026

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