Malignant peripheral nerve sheath tumor of the ileocecal region: a case report

By
Yiqian Luo
Yuanyuan Wang
Rentong Liu
Yiwei Cheng
Chengjie Gan
Bing Li
July 3, 2026
0 min

Frontiers In Oncology

Background

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas that infrequently occur in the gastrointestinal tract, particularly the colon. Fewer than ten cases of primary colonic MPNST have been documented.

Data Highlights

No numerical or trial data is available in the source material.

Key Findings

The patient presented with right lower abdominal pain and a palpable mass.
Imaging studies suggested a malignant neoplasm with lymph node involvement.
Endoscopic biopsy indicated high-grade mucosal intraepithelial neoplasia but did not confirm malignancy.
The definitive diagnosis of MPNST was made postoperatively through pathological examination and immunohistochemistry.
Six months post-surgery, there was no evidence of recurrence or metastasis.

Clinical Implications

This case underscores the diagnostic challenges associated with MPNST in atypical locations such as the ileocecal region. Surgical resection with clear margins remains the preferred treatment approach, necessitating careful pathological evaluation for accurate diagnosis.