Prospective randomised controlled trial to compare tissue reactions and scarring with polypropylene versus polyglactin 910 sutures in periocular skin

By
Tessa Fayers
John S Vekinis
Laura Ah-Kye
David Parham
Priscilla Anketell
Justin Weir
Roger A’Hern
Ben Parkin
July 1, 2026
0 min

British Journal Of Ophthalmology

Overview

This study compares the histological tissue inflammatory reactions and clinical scarring associated with polypropylene (Prolene) and polyglactin 910 (Vicryl) sutures in periocular skin.

Background

The choice of suture material in oculoplastic surgery is critical due to its potential impact on tissue healing and cosmetic outcomes. Different suture materials can provoke varying inflammatory responses, which may affect recovery and long-term scarring. Understanding these differences is essential for optimizing surgical outcomes in eyelid procedures.

Data Highlights

No numerical data or trial results were provided in the source material.

Key Findings

Prolene sutures may result in less short-term histological inflammatory reaction compared to Vicryl.
Long-term clinical scarring is reported as very good for both Prolene and Vicryl sutures.
Some patients using Vicryl developed clinical granulomas, potentially necessitating further surgical intervention.
In patients prone to significant scarring, Prolene may pose a lower risk of inflammatory response than Vicryl.
The study was conducted across two sites and adhered to ethical standards.

Clinical Implications

The choice of suture should consider the characteristics of the material and the patient's specific needs.

Conclusion

The study highlights the importance of suture material selection in oculoplastic surgery, particularly regarding inflammatory responses and scarring outcomes. Both Prolene and Vicryl have their advantages, but Prolene may be preferable in certain patient populations.