Link Between Aspirin Consumption and Deterioration of Intrinsic Capacity in Elderly

Overview

This study investigates the relationship between aspirin use and intrinsic capacity deterioration in older adults. Findings indicate that aspirin use is associated with negative sensory outcomes.

Background

The aging global population presents significant public health challenges, particularly regarding the health of older adults. Intrinsic capacity (IC) is a critical measure of health in this demographic, encompassing various functional domains. Understanding the impact of medications like aspirin on IC is essential for optimizing health outcomes in elderly populations.

Data Highlights

Key Findings

• Aspirin use alone was not significantly correlated with severe loss of intrinsic capacity.
• Aspirin was linked to negative outcomes in sensory function, particularly vision and hearing.
• The combination of aspirin with ACEI or ARBs was associated with a significant reduction in the incidence of severe loss of intrinsic capacity.
• There was variability in the relationship between aspirin use and sensory function outcomes based on sex.
• 41.2% of older adults in the community exhibit impaired intrinsic capacity.

Clinical Implications

Clinicians should be aware of the potential sensory side effects associated with aspirin use in older adults.

Conclusion

The study examines the relationship between aspirin use and intrinsic capacity in older adults, focusing on its effects on sensory functions.

Related Resources & Content

1. JAMA Network Open, 2023 -- Long-Term Outcomes of a Multicenter Aspirin Deprescribing Intervention
2. JAMA Network Open, 2023 -- The Impact of Meat Intake on Cognitive Function Across Different APOE Genotypes
3. European Journal of Preventive Cardiology, 2023 -- Reevaluating Aspirin's Role in Primary Prevention: Addressing Existing Discrepancies
4. WHO, 2025 -- Integrated care for older people (ICOPE): guidance for person-centred assessment and pathways in primary care, 2nd ed
5. U.S. Preventive Services Taskforce, 2022 -- Final Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication
6. Drugs - Real World Outcomes — Inappropriate Medication Usage Among Community-Dwelling Older Adults with Alzheimer’s Disease and Related Dementias: A Cross-Sectional Study
7. Integrated care for older people (‎ICOPE)‎: guidance for person-centred assessment and pathways in primary care, 2nd ed
8. Final Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication | United States Preventive Services Taskforce
9. Acute kidney injury and morbi‐mortality associated with “triple whammy” combination: Systematic review and meta‐analysis - PMC
10. Frontiers | The association of polypharmacy with intrinsic capacity: an analysis of the WHO ICOPE pilot data from Lianyungang, China