Comparison of subxiphoid and lateral intercostal approaches for video-assisted thoracoscopic extended thymectomy: a retrospective cohort study - Report - MDSpire

Comparison of subxiphoid and lateral intercostal approaches for video-assisted thoracoscopic extended thymectomy: a retrospective cohort study

  • By

  • Shuai Shi

  • Zhenlin Jiang

  • Zuxin Dong

  • Junting Chen

  • Jianhua Yan

  • June 22, 2026

  • 0 min

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Clinical Report: Evaluation of Subxiphoid Versus Lateral Intercostal Techniques in VATET

Overview

This study compares the perioperative, neurological, and short-term oncologic outcomes of subxiphoid and lateral intercostal approaches in video-assisted thoracoscopic extended thymectomy (VATET).

Background

Thymoma is the most common primary tumor of the anterior mediastinum, and surgical resection is critical for effective treatment. Video-assisted thoracoscopic surgery (VATS) has emerged as a minimally invasive alternative to traditional sternotomy, offering potential benefits such as reduced blood loss and shorter recovery times. The choice of surgical approach remains a topic of debate, with the subxiphoid and lateral intercostal techniques being the most commonly utilized.

Data Highlights

OutcomeSubxiphoid Approach (SA)Lateral Intercostal Approach (ICA)
Intraoperative Blood LossHigherLower
Postoperative StayLongerShorter
Drainage DurationLongerShorter
Hospitalization CostsHigherLower
Postoperative Pain (VAS)HigherLower
Complication Rates8.24%6.02%
Thymoma Recurrence2 patients2 patients

Key Findings

  • Both subxiphoid and lateral intercostal approaches are safe for VATET.
  • The ICA group exhibited lower intraoperative blood loss compared to the SA group.
  • Postoperative hospital stay and drainage duration were shorter in the ICA group.
  • VAS scores for postoperative pain were significantly lower in the ICA group.
  • Complication rates were comparable between both approaches.
  • Neurological outcomes in myasthenia gravis were similar across both groups.

Clinical Implications

Surgeons may consider the lateral intercostal approach for improved operative efficiency, while the subxiphoid approach may be preferred for minimizing early postoperative pain. Both techniques maintain similar safety profiles and oncologic outcomes.

Conclusion

In conclusion, both the subxiphoid and lateral intercostal approaches are viable for VATET, with distinct advantages that may guide surgical decision-making based on patient needs.

Related Resources & Content

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  5. NCCN Guidelines Version 1.2024, NCCN, 2023 -- Principles of Surgical Resection
  6. NCCN Clinical Practice Guidelines In Oncology, PubMed, 2024 -- Thymomas and Thymic Carcinomas
  7. The Society of Thoracic Surgeons Expert Consensus Document, CoLab, 2024 -- Surgical Management of Thymomas
  8. Langenbeck's Archives of Surgery, 2026 -- Perioperative efficacy of subxiphoid and intercostal thoracoscopic thymectomy
  9. NCCN Guidelines Version 1.2024
  10. Thymomas and Thymic Carcinomas, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology
  11. The Society of Thoracic Surgeons Expert Consensus Document on the Surgical Management of Thymomas | CoLab
  12. Perioperative efficacy of subxiphoid and intercostal thoracoscopic thymectomy: a systematic review and meta-analysis | Langenbeck's Archives of Surgery | Springer Nature Link
  13. Frontiers | Feasibility of Video-Assisted Thoracoscopic Surgery via Subxiphoid Approach in Anterior Mediastinal Surgery: A Meta-Analysis
  14. Comparison of Short-Term Quality of Life Between Subxiphoid and Lateral Intercostal Approaches Thoracoscopic Thymectomy for Nonmyasthenic Early-Stage Thymoma: A Prospective Study - ScienceDirect
  15. Randomized Trial of Thymectomy in Myasthenia Gravis - PMC
  16. Long-term effect of thymectomy in patients with non-thymomatous myasthenia gravis treated with prednisone: 2-year extension of the MGTX randomised trial - PMC
  17. Thymectomy for Myasthenia Gravis (Practice Parameter Update)
  18. Standardized definitions and policies of minimally invasive thymoma resection - PMC

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