Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers - Report - MDSpire
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Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers
Dysregulation of Zinc Homeostasis in Older Adults with Acute Ischemic Stroke
Overview
This study investigates the relationship between zinc homeostasis dysregulation and acute ischemic stroke in elderly patients. Key findings indicate significant alterations in serum zinc, metallothionein levels, and oxidative stress markers in stroke patients compared to healthy controls.
Background
Ischemic stroke is a leading cause of mortality and disability, particularly among the elderly. Understanding the role of trace elements like zinc in stroke pathophysiology may help identify modifiable risk factors and improve patient outcomes. This study focuses on the interplay between zinc homeostasis, oxidative stress, and inflammation in older adults with acute ischemic stroke.
Data Highlights
Parameter
Stroke Patients
Controls
p-value
Serum Zinc (μg/dL)
75.78 ± 20.39
97.94 ± 18.35
< 0.001
MT-1 (ng/mL)
8.61 ± 3.29
12.85 ± 3.57
< 0.001
FADS1 Activity Index
0.50 ± 0.11
0.39 ± 0.09
< 0.001
8-OHdG (ng/mL)
7.96 ± 2.26
4.17 ± 1.31
< 0.001
hs-CRP (mg/L)
6.63 ± 5.66
2.56 ± 1.78
< 0.001
IL-6 (pg/mL)
8.80 ± 5.44
3.80 ± 2.11
< 0.001
MDA (nmol/mL)
6.07 ± 1.92
3.88 ± 1.11
< 0.001
SOD (U/mL)
98.83 ± 24.85
127.83 ± 22.52
< 0.001
Key Findings
Stroke patients had significantly lower serum zinc levels compared to controls (75.78 ± 20.39 vs. 97.94 ± 18.35 μg/dL, p < 0.001).
Metallothionein-1 (MT-1) levels were also significantly lower in stroke patients (8.61 ± 3.29 vs. 12.85 ± 3.57 ng/mL, p < 0.001).
Elevated FADS1 activity index was observed in stroke patients (0.50 ± 0.11 vs. 0.39 ± 0.09, p < 0.001).
Increased levels of oxidative stress marker 8-OHdG were found in stroke patients (7.96 ± 2.26 vs. 4.17 ± 1.31 ng/mL, p < 0.001).
Significant alterations in inflammatory markers such as hs-CRP and IL-6 were noted in stroke patients compared to controls.
The combined biomarker panel showed superior discriminative performance for stroke (AUC = 0.970).
Clinical Implications
The findings highlight the potential role of zinc and metallothionein as biomarkers for ischemic stroke risk in elderly patients. Monitoring these parameters may assist in understanding the pathophysiological mechanisms underlying stroke and guide future research on therapeutic interventions.
Conclusion
Zinc homeostasis dysregulation is significantly associated with acute ischemic stroke in elderly patients. Further prospective studies are warranted to validate these findings and explore their implications for risk stratification.
