Clinical Report: Evaluating the Discriminative Efficacy of CVAI for MAFLD

Overview

This study evaluates the discriminative performance of the Chinese Visceral Adiposity Index (CVAI) compared to traditional insulin resistance metrics for identifying metabolic dysfunction-associated fatty liver disease (MAFLD) in Chinese adults with type 2 diabetes mellitus (T2DM).

Background

Metabolic dysfunction-associated fatty liver disease (MAFLD) is prevalent among patients with type 2 diabetes mellitus (T2DM). The need for reliable, non-invasive screening tools is critical, as traditional diagnostic methods like liver biopsy are not suitable for widespread use. The CVAI has been developed to assess visceral adipose dysfunction, but its efficacy compared to other insulin resistance indices requires further investigation.

Data Highlights

Key Findings

• 1,313 out of 2,945 participants (44.6%) were diagnosed with MAFLD.
• All insulin resistance indices were independently associated with MAFLD (P < 0.001).
• CVAI had the highest discriminative ability (AUC = 0.754).
• Adding CVAI to the baseline model significantly improved risk reclassification (NRI = 0.598, IDI = 0.081).
• The association between CVAI and MAFLD was stronger in females and older adults (P for interaction < 0.05).
• RCS analysis indicated a predominantly linear relationship (non-linear P = 0.0581).

Clinical Implications

Further studies are needed to validate the diagnostic utility of CVAI for identifying MAFLD in T2DM patients.

Conclusion

Further prospective studies are needed to validate the diagnostic utility of CVAI.

Related Resources & Content

1. Author(s)/Org, Source, Year -- Title
2. Frontiers in Endocrinology — Comparison of the association and discriminatory ability of CVAI, LAP, CI, and AVI for type 2 diabetes in Chinese adults aged ≥ 50 years: a sex-specific analysis
3. Frontiers in Endocrinology — Comparative discriminatory performance of emerging endocrine-metabolic indices versus obesity indices for cardiometabolic multimorbidity in older adults: a cross-sectional study
4. Frontiers in Endocrinology — Visceral fat area and visceral-to-subcutaneous fat ratio are more strongly associated with residual cholesterol than conventional anthropometric indices in adults with type 2 diabetes
5. Frontiers in Endocrinology — Quantifying the metabolic-inflammatory axis: synergistic value of TyG index and FAI in assessing CAD risk among MAFLD patients
6. A multisociety Delphi consensus statement on new fatty liver disease nomenclature
7. Association between Chinese visceral adiposity index and metabolic-associated fatty liver disease in Chinese adults with type 2 diabetes mellitus
8. Prediction of MASLD using different screening indexes in Chinese type 2 diabetes mellitus | Diabetology & Metabolic Syndrome | Springer Nature Link