Music Listening and Multiple Dimensions of Well-Being in Acute Stroke: A Randomized Clinical Trial - Report - MDSpire

Music Listening and Multiple Dimensions of Well-Being in Acute Stroke: A Randomized Clinical Trial

  • By

  • Giacomo Giacalone

  • Silvia De Boni

  • Sara Pezzotta

  • Emanuele Dotto

  • Francesca Colombo

  • Raffaella Chieffo

  • Mario Orrico

  • Miryam Cannizzaro

  • Mor Gueye

  • Massimo Filippi

  • Luisa Roveri

  • July 17, 2026

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Clinical Report: The Impact of Music Listening on Well-Being in Acute Stroke Patients

Overview

This randomized clinical trial evaluated the feasibility and effects of personalized vocal music listening on psychological well-being in acute stroke patients. Results indicated improvements in mood and sleep quality, with high acceptability among participants.

Background

Acute stroke can lead to significant psychological distress, impacting recovery and quality of life. Music therapy has emerged as a potential intervention to enhance emotional and cognitive outcomes in stroke rehabilitation.

Data Highlights

OutcomeMusic GroupControl GroupP-value
HADS-D−2.68 (95% CI, −3.90 to −1.47)Baseline<.001
HADS-A−1.86 (95% CI, −2.93 to −0.79)Baseline<.001
ISI−2.83 (95% CI, −4.43 to −1.24)Baseline<.001
EQ-VAS−0.19 (95% CI, −6.03 to 5.64)Baseline.94
Dropout Rate6.7%Baseline

Key Findings

  • Enrollment rate was 91%, with a dropout rate of 6.7%.
  • More than 80% of participants rated the music intervention as highly acceptable.
  • Music listening significantly reduced HADS-D and HADS-A scores compared to standard care.
  • Improved sleep quality was observed in the music group, as indicated by lower ISI scores.
  • No adverse events related to the music intervention were reported.

Clinical Implications

The findings indicate that structured music listening can be a feasible and acceptable intervention for improving mood and sleep quality in acute stroke patients.

Conclusion

This study supports the use of personalized music listening during acute stroke hospitalization.

Related Resources & Content

  1. JAMA Network, 2026 -- Music Listening and Multiple Dimensions of Well-Being in Acute Stroke: A Randomized Clinical Trial
  2. NICE, 2023 -- Recommendations | Stroke rehabilitation in adults | Guidance
  3. AHA/ASA, 2016 -- Guidelines for Adult Stroke Rehabilitation and Recovery
  4. Frontiers in Neurology — A structured music-based intervention for motor rehabilitation and exploratory cognitive and quality-of-life outcomes after stroke: a study protocol for a randomized waitlist-controlled intervention study
  5. Frontiers in Psychiatry — Effects of bifrontal-transcranial direct current stimulation combined with music listening on sleep quality, cortical activation and functional connectivity in patients with insomnia: a randomized controlled trial by fNIRS
  6. Impact of Preferred Musical Selections on Performance in Laparoscopic Surgery: A Randomized Crossover Investigation
  7. Frontiers in Psychiatry — Effects of transcutaneous auricular vagus nerve stimulation on patients with post-stroke insomnia: a randomized controlled trial protocol
  8. Recommendations | Stroke rehabilitation in adults | Guidance | NICE
  9. 2016-05-04_Adult Stroke Rehab_slides
  10. Music Listening and Multiple Dimensions of Well-Being in Acute Stroke: A Randomized Clinical Trial | Neurology | JAMA Network Open | JAMA Network
  11. https://karger.com/ced/article-pdf/doi/10.1159/000543361/4319860/000543361.pdf
  12. Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs - PMC
  13. Effects of personalized music listening on post-stroke cognitive impairment: A randomized controlled trial - PubMed

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