Transcriptomic signatures and immune microenvironment of acute rejection after heart transplantation: an integrated bioinformatics analysis - Report - MDSpire

Transcriptomic signatures and immune microenvironment of acute rejection after heart transplantation: an integrated bioinformatics analysis

  • By

  • Wenjun Zhou

  • Langjing Huang

  • Wenwen Tang

  • May 25, 2026

  • 0 min

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Clinical Report: Gene Expression Profiles and Immune Landscape in Acute Heart Transplant Rejection

Overview

{'suggestion': "Define 'compact gene signature' more clearly."}

Background

{'suggestion': 'List specific limitations of EMB, such as sampling variability and inter-observer differences.'}

Data Highlights

{'suggestion': 'Include actual Log2 Fold Change values for the genes listed.'}

Key Findings

{'suggestion': 'State the number of significant pathways identified in the enrichment analysis.'}

Clinical Implications

{'suggestion': 'Discuss potential challenges in integrating molecular assays with traditional histology.'}

Conclusion

{'suggestion': 'Propose specific next steps for further validation in larger cohorts.'}

Related Resources & Content

  1. Frontiers in Cardiovascular Medicine, 2026 -- Artificial intelligence optimizes immune rejection prediction and management in heart transplantation: a structured narrative review
  2. the pathologist, 2026 -- Next-generation Graft Health Monitoring
  3. Basic Research in Cardiology, 2009 -- Inhibition of Acute Rejection in Mouse Heart Transplants Using STAT-1 Decoy Oligodeoxynucleotides
  4. ISHLT Guidelines for the Care of Heart Transplant Recipients | ISHLT
  5. Donor-derived cell-free dna as a diagnostic biomarker for acute rejection in heart transplantation: A systematic review and meta-analysis - PubMed
  6. Genetic Variants in Nucleotide Factor of Activated T Cells Cytoplasmic 2 and 4 Associated with Acute Rejection Risk After Kidney Transplantation
  7. ISHLT Guidelines for the Care of Heart Transplant Recipients | ISHLT
  8. Donor-derived cell-free dna as a diagnostic biomarker for acute rejection in heart transplantation: A systematic review and meta-analysis - PubMed
  9. Redefining the molecular rejection states in 3230 heart transplant biopsies: Relationships to parenchymal injury and graft survival - ScienceDirect

Original Source(s)

Transcriptomic signatures and immune microenvironment of acute rejection after heart transplantation: an integrated bioinformatics analysis

  • by Wenjun Zhou, Langjing Huang, Wenwen Tang

  • May 25, 2026

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