Large endometrial polyps in postmenopausal women lacking hormonal influence: a case study and review of existing literature - Report - MDSpire

Large endometrial polyps in postmenopausal women lacking hormonal influence: a case study and review of existing literature

  • By

  • Danlin Wang

  • Li Wang

  • Ning Zhou

  • Yan Fang

  • April 20, 2026

  • 0 min

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Clinical Report: Large Endometrial Polyps in Postmenopausal Women

Overview

This report summarizes the clinical presentation and management of giant endometrial polyps (EPs) in postmenopausal women without hormonal exposure. The findings indicate that these polyps are rare, predominantly benign, and often present with postmenopausal bleeding.

Background

Giant endometrial polyps are a significant concern in postmenopausal women due to their potential to mimic malignancy and the associated risks of unnecessary surgical interventions. Understanding their clinical characteristics is crucial for appropriate management and to mitigate the risk of misdiagnosis. This study highlights the importance of accurate diagnostic techniques in evaluating postmenopausal bleeding.

Data Highlights

Age RangePolyp Diameter (cm)ManagementHistology
55-704.0-12.0Hysteroscopic polypectomy, TAH-BSO, D&C11/15 benign

Key Findings

  • Fifteen postmenopausal women with giant EPs were studied, with ages ranging from 55 to 70 years.
  • The most common symptom was postmenopausal bleeding (PMB).
  • Surgical interventions included hysteroscopic polypectomy and total abdominal hysterectomy with bilateral salpingo-oophorectomy.
  • Most polyps (11 out of 15) were found to be benign on histology.
  • Transvaginal sonography (TVS) is recommended as the first-line evaluation method.
  • Diagnostic hysteroscopy with complete polypectomy is the gold standard for histopathological assessment.

Clinical Implications

Clinicians should maintain a high index of suspicion for giant endometrial polyps in postmenopausal women presenting with PMB, even in the absence of hormonal exposure. Early and accurate diagnosis through TVS and hysteroscopy can prevent unnecessary aggressive surgical procedures.

Conclusion

Giant endometrial polyps in postmenopausal women, while rare, are predominantly benign and require careful evaluation to avoid misdiagnosis and overtreatment. This study underscores the importance of appropriate diagnostic approaches in managing postmenopausal bleeding.

References

  1. ACOG, ACOG, 2026 -- ACOG Publishes Updated Guidance on Evaluation of Postmenopausal Bleeding
  2. British Fertility Society, 2026 -- Management of endometrial polyps in fertility: British fertility Society policy and practice guideline
  3. The Journal of Clinical Endocrinology & Metabolism — Evaluating Patients: Navigating Diagnostic Obstacles in Polycystic Ovary Syndrome Assessment
  4. Correspondence: Recurring Gastrointestinal Symptoms Associated with Isolated Endometriosis in a Middle-Aged Woman
  5. Evaluating the Safety of Endoscopic Mucosal Resection for Large Non-Pedunculated Colorectal Adenomas in Older Adults
  6. European Journal of Preventive Cardiology — Addressing Polycystic Ovary Syndrome to Mitigate Cardiovascular Disease Risk
  7. ACOG Publishes Updated Guidance on Evaluation of Postmenopausal Bleeding | ACOG
  8. Full article: Management of endometrial polyps in fertility: British fertility Society policy and practice guideline

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