Phytomedicines in preclinical and clinical research on antipsychotics-induced EPS/EPS-like behaviors: therapeutic effects and neurobiological mechanisms - Report - MDSpire
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Phytomedicines in preclinical and clinical research on antipsychotics-induced EPS/EPS-like behaviors: therapeutic effects and neurobiological mechanisms
Clinical Report: Herbal Medicines in the Prevention and Treatment of EPS
Background
Extrapyramidal syndrome (EPS) is a significant side effect of antipsychotic medications, leading to movement disorders that can severely impact patient quality of life. The management of EPS is challenging, as current treatments often do not fully prevent these symptoms. Understanding alternative therapies, such as herbal medicines, is crucial.
Data Highlights
Most studies reviewed are animal studies demonstrating that herbal medicines can prevent or improve EPS-like behaviors. Some clinical research indicates beneficial effects of herbal medicines on EPS in patients with schizophrenia.
Key Findings
Herbal medicines have shown potential in preventing and treating EPS induced by antipsychotic drugs.
Neurobiological mechanisms include regulating monoaminergic neurotransmission and alleviating oxidative stress.
Herbal treatments may help maintain mitochondrial function and suppress neuroinflammation.
Combination therapy of herbal medicines with antipsychotics may enhance treatment efficacy for EPS.
Existing clinical research supports the use of phytomedicines alongside traditional antipsychotic therapies.
Clinical Implications
Clinicians should consider the use of phytomedicines while monitoring for efficacy and safety.
Conclusion
The findings indicate that herbal medicines could play a role in the prevention and management of EPS.
