Pre-Diagnosis Weight Loss in First-Episode Psychosis Linked to Future Weight Gain

Overview

This study investigates the prevalence of weight loss prior to the diagnosis of first-episode psychosis (FEP) and its impact on subsequent weight gain. Findings indicate that individuals with pre-FEP weight loss gain weight post-diagnosis at more than double the rate of those without prior weight loss.

Background

Weight gain is a common and rapid occurrence in individuals experiencing first-episode psychosis. Understanding pre-diagnosis weight changes is crucial, as they may influence post-treatment weight trajectories. This study aims to investigate pre-FEP weight loss and its association with future weight gain.

Data Highlights

Key Findings

• 53% of individuals experienced weight loss prior to FEP diagnosis.
• Individuals with pre-FEP weight loss gained weight post-diagnosis at a rate of 8.93% body weight per year compared to 4.07% for those without prior loss.
• Each 1% of pre-FEP weight loss predicted an additional 0.41% annual weight gain post-diagnosis.
• Average weight gain in the first year post-diagnosis (6.49 kg) exceeded average weight loss prior to diagnosis (4.83 kg).
• Findings were consistent across sensitivity analyses.

Clinical Implications

Clinicians should inquire about weight changes during the pretreatment phase in individuals with FEP, as this may predict weight gain following diagnosis.

Conclusion

Pre-diagnosis weight loss is prevalent in first-episode psychosis and is associated with subsequent weight gain.

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