Clinical Report: Relationship Between Preoperative SII and Postoperative Optical Quality

Overview

This study investigates the association between preoperative systemic immune-inflammation index (SII) and early postoperative optical quality following cataract surgery. Higher preoperative SII was linked to lower internal modulation transfer function (MTF) average height at 1 week and 1 month post-surgery.

Background

Understanding factors that influence early postoperative recovery after cataract surgery is crucial for optimizing patient outcomes. Systemic inflammation, as indicated by the SII, may play a significant role in this variability. This study provides insights into how preoperative inflammatory status can affect optical quality, which is essential for improving surgical strategies and patient care.

Data Highlights

Key Findings

• Higher preoperative log2-SII correlates with lower internal MTF average height at 1 week and 1 month post-surgery.
• No significant association was found at 1 day postoperative (P = 0.299).
• The low-SII group exhibited better internal Strehl ratio and lower higher-order aberrations at 1 month.
• Postoperative visual acuity remained comparable across SII groups at all time points.
• Exploratory analyses indicated potential differences in dysfunctional lens index and objective scatter index at 1 month.

Clinical Implications

Clinicians should consider preoperative systemic inflammatory status when evaluating potential postoperative recovery trajectories in cataract surgery patients. Implementing anti-inflammatory strategies may enhance early optical recovery and overall patient satisfaction.

Conclusion

The findings suggest that systemic inflammation, as measured by SII, may influence early optical recovery after cataract surgery, highlighting the need for further research in this area.

Related Resources & Content

1. Ophthalmology Management, 2025 -- Inflammatory Cytokines Persist Years After Cataract Surgery
2. Ophthalmology Management, 2021 -- Postoperative care for modern cataract surgery
3. The Ophthalmologist, 2026 -- The New Era of Postoperative Inflammation Management
4. European Society of Cataract and Refractive Surgeons Guideline for Cataract Surgery, 2025
5. Frontiers, 2026 -- Association Between Systemic Immune-Inflammation Index and Postoperative Optical Quality
6. the ophthalmologist — Optimizing the Ocular Surface Before and After Cataract Surgery
7. European Society of Cataract and Refractive Surgeons Guideline for Cataract Surgery
8. Frontiers | Association Between Systemic Immune-Inflammation Index and Postoperative Optical Quality
9. Advanced vs. Standard Monofocal IOLs: Optical Quality and Patient-Perceived Visual Outcomes - PubMed