fMRI-Directed rTMS Targeting V1 Alleviates Depressive Symptoms in Young Individuals with Bipolar Disorder: Results from a Double-Blind Randomized Controlled Study - Report - MDSpire

fMRI-Directed rTMS Targeting V1 Alleviates Depressive Symptoms in Young Individuals with Bipolar Disorder: Results from a Double-Blind Randomized Controlled Study

  • By

  • Xudong Zhao

  • Hetong Zhou

  • Xiaomei Zhang

  • Ruoyu Tang

  • Yimei Gan

  • Tongjie Zhuang

  • Yiyi Zhu

  • Zeyu Qin

  • Yiqing Chen

  • Yaoyang Fu

  • Danhua Zhang

  • Le Xu

  • Shiliang Wang

  • Zhongxia Shen

  • Shaohua Hu

  • Minmin Wang

  • March 7, 2026

  • 0 min

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Clinical Report: fMRI-Directed rTMS Targeting V1 Alleviates Depressive Symptoms

Overview

{'age_range': "Specify the age range of 'young individuals' (e.g., 12-25 years)."}

Background

{'statistics': 'Include specific statistics or references regarding the management challenges of depressive symptoms in bipolar disorder.'}

Data Highlights

{'numerical_values': 'Add numerical values for the changes in MADRS scores at week 3 and week 8.'}

Key Findings

{'magnitude': 'Include the specific percentage or point reduction in MADRS scores.'}

Clinical Implications

{'side_effects': 'Discuss potential side effects or limitations of rTMS.'}

Conclusion

{'future_research': 'Propose specific areas for further exploration in clinical practice.'}

References

  1. BMC Psychiatry (Springer), 2025 -- Impact of Enhanced Intermittent Theta Burst Stimulation on Depressive Symptoms and Cognitive Abilities in Adolescents with Bipolar Disorder
  2. BMC Psychiatry (Springer), 2025 -- Characterising resting motor threshold in depressed individuals across life span: a large retrospective study
  3. Frontiers in Psychiatry, 2026 -- Exploring the Efficacy of Low-Frequency Transcranial Magnetic Stimulation for Sensory and Behavioral Improvements in Pediatric Autism Spectrum Disorder: A Randomized Study
  4. Consensus review and considerations on TMS to treat depression, ScienceDirect, 2024
  5. Danish Psychiatric Society’s 2025 TMS guideline
  6. BMC Psychiatry (Springer) — Neural Network Associations with Response Inhibition Linked to Antidepressant Efficacy in Major Depressive Disorder
  7. NeuroStar® Advanced Therapy Receives FDA Clearance as a First-Line Add-On Treatment for Adolescents with Depression
  8. Defining Treatment‐Resistant Bipolar Depression: Recommendations From the ISBD Task Force
  9. Consensus review and considerations on TMS to treat depression: A comprehensive update endorsed by the National Network of Depression Centers, the Clinical TMS Society, and the International Federation of Clinical Neurophysiology - ScienceDirect
  10. TMS GUIDELINES
  11. Accelerated Intermittent Theta-Burst Stimulation and Treatment-Refractory Bipolar Depression: A Randomized Clinical Trial - PMC
  12. Efficacy and safety of repetitive transcranial magnetic stimulation in youth with depression: a systematic review and meta-analysis of randomized sham-controlled trials - PMC
  13. Effectiveness of personalized repetitive transcranial magnetic stimulation for major depressive disorder: A systematic review and meta-analysis of randomized active-controlled trials - ScienceDirect
  14. A Systematic Review and Meta-Analysis of Randomized Sham-Controlled Trials of Repetitive Transcranial Magnetic Stimulation for Bipolar Disorder | Psychiatric Quarterly

Original Source(s)

fMRI-Directed rTMS Targeting V1 Alleviates Depressive Symptoms in Young Individuals with Bipolar Disorder: Results from a Double-Blind Randomized Controlled Study

  • by Xudong Zhao, Hetong Zhou, Xiaomei Zhang, Ruoyu Tang, Yimei Gan, Tongjie Zhuang, Yiyi Zhu, Zeyu Qin, Yiqing Chen, Yaoyang Fu, Danhua Zhang, Le Xu, Shiliang Wang, Zhongxia Shen, Shaohua Hu, Minmin Wang

  • March 7, 2026

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