Giant sellar aneurysm presenting with arginine vasopressin deficiency: a rare case report - Report - MDSpire

Giant sellar aneurysm presenting with arginine vasopressin deficiency: a rare case report

  • By

  • Xiaolong Zhang

  • Pengfei Wang

  • Baogen Pan

  • June 3, 2026

  • 0 min

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Clinical Report: Uncommon Presentation of a Giant Sellar Aneurysm

Overview

This report details a rare case of a giant sellar aneurysm presenting as diabetes insipidus (DI), highlighting the need for differential diagnosis beyond pituitary adenomas. The successful management of this case underscores the importance of recognizing atypical presentations of sellar lesions.

Background

Giant sellar aneurysms are rare vascular anomalies that can lead to significant neurological symptoms through compression of surrounding structures. Their presentation as diabetes insipidus is particularly uncommon, challenging traditional diagnostic approaches. Understanding these presentations is crucial for timely and accurate diagnosis, which can significantly impact patient outcomes.

Data Highlights

No numerical data or trial data presented in the article.

Key Findings

  • The patient presented with dizziness, blurred vision, and increased urine output, indicative of diabetes insipidus.
  • Non-contrast CT and MRI revealed a mass in the sellar region associated with the left internal carotid artery.
  • Laboratory tests confirmed panhypopituitarism and elevated serum osmolality.
  • The aneurysm was successfully treated with flow-diverting stent placement and coil embolization.
  • Postoperative management included hormone replacement therapy, leading to significant improvement in symptoms.

Clinical Implications

Clinicians should consider giant sellar aneurysms in the differential diagnosis of sellar masses, especially when patients present with atypical symptoms such as diabetes insipidus. Early recognition and multidisciplinary management are essential for improving patient outcomes.

Conclusion

This case emphasizes the importance of broadening the differential diagnosis for sellar lesions and highlights the successful management of a rare presentation of a giant sellar aneurysm.

Related Resources & Content

  1. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Deficiencies of Arginine Vasopressin and Oxytocin in Endocrinology Practice
  2. Clinical Rheumatology, 2022 -- Recurrent Subarachnoid Hemorrhage as a Clinical Presentation in Microscopic Polyangiitis: A Case Study and Review of Existing Literature
  3. A Report on a Ruptured Pseudoaneurysm of the Vasa Corona: Case Study and Literature Analysis, 2023
  4. Vascular Compression of the Lateral Medulla Resulting in Episodes of Hypertension, 2024
  5. Nature Reviews Endocrinology, 2024 -- Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency
  6. Clinical characteristics and treatment strategies for pituitary adenoma associated with intracranial aneurysm, 2024
  7. Evaluation of flow diverters for cerebral aneurysm therapy, 2024
  8. Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency | Nature Reviews Endocrinology
  9. Clinical characteristics and treatment strategies for pituitary adenoma associated with intracranial aneurysm | Chinese Neurosurgical Journal | Springer Nature Link
  10. Evaluation of flow diverters for cerebral aneurysm therapy: recommendations for imaging analyses in clinical studies, endorsed by ESMINT, ESNR, OCIN, SILAN, SNIS, and WFITN - PubMed

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