Hormonal Influence on Corneal Changes in Keratoconus: A Comprehensive Analysis of Tomographic and Biomechanical Differences by Gender, Age, and Menstrual Cycle - Report - MDSpire

Hormonal Influence on Corneal Changes in Keratoconus: A Comprehensive Analysis of Tomographic and Biomechanical Differences by Gender, Age, and Menstrual Cycle

  • By

  • Xiaorui Zhao

  • Ruiyu Zhang

  • Tong Sun

  • Yifei Yuan

  • Yu Zhang

  • Yueguo Chen

  • February 11, 2026

  • 0 min

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Clinical Report: Hormonal Influence on Corneal Changes in Keratoconus

Overview

This study investigates the relationship between sex hormones and corneal parameters in keratoconus (KC) patients. It highlights significant differences in corneal morphology and biomechanics based on gender, age, and menstrual cycle phases.

Background

Keratoconus is a progressive corneal disorder that can lead to severe visual impairment, particularly in adolescents and young adults. Understanding the role of sex hormones in KC may provide insights into its pathogenesis and progression, which is crucial for developing targeted therapies. This study addresses a gap in the literature regarding the hormonal influences on corneal changes in KC patients.

Data Highlights

No numerical data available in the provided source material.

Key Findings

  • Sex hormones may influence the progression of keratoconus.
  • Significant differences in corneal parameters were observed based on gender and age.
  • Female patients exhibited variations in corneal biomechanical properties across different menstrual cycle phases.
  • Tomographic and biomechanical assessments were standardized to minimize bias.
  • The study included a comprehensive evaluation of both morphological and biomechanical corneal parameters.

Clinical Implications

Clinicians should consider the potential impact of hormonal fluctuations on corneal health in female keratoconus patients, particularly during different phases of the menstrual cycle. This awareness may inform monitoring strategies and treatment decisions.

Conclusion

The findings underscore the importance of hormonal influences on corneal changes in keratoconus, suggesting a need for further research to elucidate these relationships and their clinical significance.

References

  1. Contact Lens Spectrum, 2008 -- New Findings from the 2008 Global Keratoconus Congress
  2. Contact Lens Spectrum, 2016 -- Keratoconus: When to Fit Contact Lenses Versus Refer for Surgery
  3. Optometric Management, 2017 -- CLINICAL: CORNEA
  4. ESCRS -- The Second Global Consensus on Keratoconus
  5. Sex Hormones and Keratoconus: In Search of the Link - PMC
  6. Contact Lens Spectrum — ONLINE PHOTO DIAGNOSIS
  7. ESCRS - The Second Global Consensus on Keratoconus
  8. Sex Hormones and Keratoconus: In Search of the Link - PMC
  9. SPS-310 Corneal Crosslinking II | ASCRS

Original Source(s)

Hormonal Influence on Corneal Changes in Keratoconus: A Comprehensive Analysis of Tomographic and Biomechanical Differences by Gender, Age, and Menstrual Cycle

  • by Xiaorui Zhao, Ruiyu Zhang, Tong Sun, Yifei Yuan, Yu Zhang, Yueguo Chen

  • February 11, 2026

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