Machine learning clustering of psychological response trajectories across the first and second waves of the COVID-19 pandemic - Report - MDSpire

Machine learning clustering of psychological response trajectories across the first and second waves of the COVID-19 pandemic

  • By

  • Fardous Hasan

  • Farzana Haque

  • Roberto Ariel Abeldaño Zuñiga

  • Nourhan M. Aly

  • Moréniké Oluwátóyìn Foláyan

  • June 26, 2026

  • 0 min

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Clinical Report: Clustering Psychological Response Patterns Using Machine Learning

Overview

This study identifies three psychological response clusters among adults during the COVID-19 pandemic, highlighting the dynamic nature of mental health across two waves.

Background

The COVID-19 pandemic has led to widespread psychological distress. This study aims to examine how psychological clusters evolve across pandemic waves.

Data Highlights

ClusterWave 1 (%)Wave 2 (%)
Resilient (low-distress, high-coping)35.529.0
Low-coping40.0449.11
High-distress25.0621.89

Key Findings

  • Three clusters emerged: resilient, low-coping, and high-distress.
  • 55.3% of participants remained in the same cluster across waves.
  • 55.8% of those in the resilient cluster transitioned to higher-distress clusters by Wave 2.
  • The low-coping cluster exhibited the greatest stability at 68.9%.
  • Older age, higher education, and employment were associated with the resilient cluster.
  • Younger age and unemployment correlated with higher distress levels.

Clinical Implications

Understanding the dynamic nature of psychological responses during crises can inform targeted interventions. Strengthening coping skills and addressing socioeconomic factors may enhance mental health support strategies.

Conclusion

The study highlights the heterogeneous nature of psychological responses during the COVID-19 pandemic.

Related Resources & Content

  1. Analysis of Clustering Patterns Identifies Distinct Profiles Linking Long-Term Post-COVID Symptoms, Initial COVID-19 Symptoms at Hospital Admission, and Prior Medical Comorbidities in Survivors of Hospitalized COVID-19, 2022
  2. Interpretable machine learning for classification and risk factor identification of anxiety, depression, and insomnia symptoms after the full opening of China’s COVID-19 lockdown, 2025
  3. Exploring the Connection Between Anxiety and Depression During COVID-19: A Longitudinal Analysis Using Network Approaches, 2025
  4. Resource Use Patterns in US Telehealth Services: Machine Learning and Clustering Analysis Across 4 Specialties, 2026
  5. Mental health in emergencies, WHO, 2025
  6. A Multi-site, longitudinal investigation of emerging adult mental health across multiple stages of the COVID-19 pandemic, Scientific Reports, 2025
  7. Mental health in emergencies
  8. A Multi-site, longitudinal investigation of emerging adult mental health across multiple stages of the COVID-19 pandemic | Scientific Reports
  9. Frontiers | Latent classes of resilience in a nationwide sample of US adults during COVID-19 pandemic

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