The Clinical Frailty Scale (CFS) as an Independent Prognostic Factor for Patients ≥80 Years with Small Bowel Obstruction (SBO) - Report - MDSpire

The Clinical Frailty Scale (CFS) as an Independent Prognostic Factor for Patients ≥80 Years with Small Bowel Obstruction (SBO)

  • By

  • Vito Laterza

  • Marcello Covino

  • Carlo Alberto Schena

  • Andrea Russo

  • Sara Salini

  • Davide Della Polla

  • Nicola de’Angelis

  • Giuseppe Quero

  • Vincenzo Tondolo

  • Antonio La Greca

  • Giuseppe Merra

  • Gabriele Sganga

  • Antonio Gasbarrini

  • Francesco Franceschi

  • Francesco Landi

  • Sergio Alfieri

  • Fausto Rosa

  • September 6, 2023

  • 0 min

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Clinical Frailty Scale Predicts Mortality in Octogenarians with Small Bowel Obstruction

Overview

This study demonstrates that the Clinical Frailty Scale (CFS) is an effective standalone prognostic tool for predicting in-hospital mortality and major complications in patients aged 80 and above presenting with small bowel obstruction (SBO). A CFS score ≥7, indicating severe frailty, was identified as the optimal cutoff for risk stratification.

Background

Small bowel obstruction accounts for a significant proportion of emergency department admissions for abdominal pain, with increased incidence and mortality in patients over 80 years old due to comorbidities. The aging population is expected to grow substantially, making frailty assessment critical in this heterogeneous group. The Clinical Frailty Scale (CFS) is a validated tool for assessing frailty and predicting outcomes in various clinical settings, but its utility in elderly patients with SBO in emergency settings had not been established prior to this study.

Data Highlights

ParameterDetails
Study DesignSingle-centre, prospective observational cohort
PopulationPatients aged ≥80 years with radiologically confirmed SBO
Study PeriodJanuary 2015 - September 2020
Sample SizeNot specified in excerpt
Frailty AssessmentClinical Frailty Scale (CFS), cutoff ≥7 for severe frailty
Primary EndpointsIn-hospital mortality and major complications (septic shock, ICU admission, death)
Statistical MethodsROC curve analysis, Youden’s index, multivariate logistic regression

Key Findings

  • The CFS score was a reliable independent predictor of in-hospital mortality in octogenarians with SBO.
  • A CFS cutoff of ≥7 (severe frailty) optimally discriminated patients at higher risk of death and major complications.
  • ROC curve analysis showed significant predictive accuracy of CFS for mortality and complications.
  • Frailty assessment via CFS outperformed chronological age and comorbidity indices alone in prognosticating outcomes.
  • Major complications included septic shock, prolonged ICU stay, and death, all associated with higher CFS scores.

Clinical Implications

Clinicians should incorporate the Clinical Frailty Scale into the initial assessment of elderly patients presenting with SBO to better stratify risk and guide management decisions. Identifying severely frail patients (CFS ≥7) can prompt more intensive monitoring and tailored therapeutic approaches to improve outcomes. The CFS provides a practical and reproducible tool to complement traditional clinical and laboratory evaluations in this vulnerable population.

Conclusion

The Clinical Frailty Scale is a valuable standalone prognostic indicator for patients aged 80 and above with small bowel obstruction, effectively predicting mortality and major complications. Its use in emergency settings can enhance risk stratification and inform clinical decision-making.

References

  1. Rockwood et al. 2005 -- A global clinical measure of fitness and frailty in elderly people
  2. World Health Organization 2022 -- Global population ageing statistics
  3. Sepsis-3 criteria 2016 -- Definition of sepsis and septic shock
  4. Charlson Comorbidity Index 1987 -- A new method of classifying prognostic comorbidity

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