Exercise dose architecture as a precision-informed developmental framework in autism spectrum disorder: a narrative review of mechanisms, sex- and development-related heterogeneity, and clinical translation - Report - MDSpire

Exercise dose architecture as a precision-informed developmental framework in autism spectrum disorder: a narrative review of mechanisms, sex- and development-related heterogeneity, and clinical translation

  • By

  • Zhenqian Zhou

  • Dianhui Peng

  • Ping Peng

  • Xiaolin Li

  • July 15, 2026

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Clinical Report: Tailoring Exercise Interventions in Autism Spectrum Disorder

Overview

This comprehensive review highlights the potential of exercise as a non-pharmacological intervention for Autism Spectrum Disorder (ASD), emphasizing the need for a precision-informed framework that considers various dimensions of exercise dose.

Background

Autism Spectrum Disorder (ASD) is characterized by diverse symptoms and functional challenges, which necessitate effective intervention strategies. Exercise has emerged as a promising approach to address difficulties in motor function, cognition, and social engagement. Understanding the nuances of exercise interventions is crucial for optimizing therapeutic outcomes in individuals with ASD.

Data Highlights

No specific numerical data or trial data provided in the article.

Key Findings

  • Exercise interventions can improve motor performance, executive functions, and social communication in individuals with ASD.
  • The effectiveness of exercise may vary based on developmental stage, gender, and individual characteristics.
  • Current literature often treats exercise as a generic intervention, lacking specificity in defining therapeutic elements.
  • A multidimensional construct of exercise dose should include factors like motor complexity and social integration.
  • Standardized reporting of exercise interventions is necessary for better clinical translation and understanding of efficacy.

Clinical Implications

A comprehensive understanding of exercise dose and its components can enhance the effectiveness of non-pharmacological strategies in clinical practice.

Conclusion

This review provides a framework for future research on exercise interventions in ASD.

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  4. Current Guidelines | odphp.health.gov -- Physical Activity Guidelines
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  7. WHO Guidelines on Physical Activity and Sedentary Behaviour
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  9. Recommendations | Autism spectrum disorder in adults: diagnosis and management | Guidance | NICE
  10. Therapeutic effects of exercise interventions for children and adolescents with Autism: An umbrella meta-analysis - ScienceDirect
  11. Effects of exercise on core symptoms in children with autism spectrum disorder: a systematic review and three-level meta-analysis | BMC Psychiatry | Springer Nature Link
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