Changes in Malondialdehyde, 8-iso-prostaglandin F2α, and Lipid Profiles Among COVID-19 Patients: Findings from South-Western Nigeria - Report - MDSpire

Changes in Malondialdehyde, 8-iso-prostaglandin F2α, and Lipid Profiles Among COVID-19 Patients: Findings from South-Western Nigeria

  • By

  • Maria Onomhaguan Ebesunun

  • Donatus Uchechukwu Ozegbe

  • Promise Chineye Nwaejigh

  • Bose Etaniamhe Orimadegun

  • Obiageri Ihuarulam Okeoma

  • January 20, 2026

  • 0 min

Share

Changes in Malondialdehyde, 8-iso-prostaglandin F2α, and Lipid Profiles Among COVID-19 Patients

Overview

This study investigates the serum levels of malondialdehyde (MDA), 8-iso-prostaglandin F2α (8-iso-PGF2α), and lipid profiles in COVID-19 patients in South-Western Nigeria. Findings indicate significant alterations in oxidative stress markers and lipid metabolism, highlighting the impact of co-infections like malaria on these biochemical parameters.

Background

Cite specific studies that demonstrate the biochemical changes in COVID-19 patients.

Data Highlights

No numerical data available in the provided material.

Key Findings

  • Elevated levels of malondialdehyde (MDA) and 8-iso-prostaglandin F2α (8-iso-PGF2α) were observed in COVID-19 patients compared to healthy controls.
  • Co-infection with malaria significantly increased oxidative stress markers in patients.
  • Lipid profiles showed lower levels of total cholesterol, LDL-C, and HDL-C in severe COVID-19 cases.
  • Inconsistent associations were noted between triglyceride levels and disease severity.
  • Post-recovery, some patients exhibited long-term dyslipidemia, indicating lasting effects of COVID-19 on lipid metabolism.

Clinical Implications

Healthcare professionals should consider the potential for altered lipid metabolism and oxidative stress in managing COVID-19 patients, particularly in regions with high malaria prevalence. Monitoring these biochemical markers may provide insights into disease severity and patient outcomes.

Conclusion

The study underscores the importance of understanding biochemical alterations in COVID-19 patients, particularly in African populations, to inform clinical management and improve patient outcomes.

References

  1. Increased thrombo-inflammatory markers as predictors of outcomes in COVID-19 patients with cardiovascular comorbidities, Clinical Research in Cardiology, 2020 -- https://link.springer.com/article/10.1007/s00392-020-01769-9
  2. Ceramide Levels in Plasma and Their Relationship with Survival Outcomes in Severe COVID-19 Cases, Open Forum Infectious Diseases, 2020 -- https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofag052/8460657
  3. Association of Fatty Liver Disease with Severe COVID-19 and Cognitive Dysfunction in Post-COVID Syndrome, Infection, 2025 -- https://link.springer.com/article/10.1007/s15010-025-02531-x
  4. Evaluation of Coagulopathy and Hemostatic Markers Related to COVID-19: A Study from a Single Center in Egypt, Infection, 2022 -- https://link.springer.com/article/10.1007/s15010-022-01917-5
  5. Therapeutics and COVID-19: living guideline, August 2025 -- https://www.who.int/publications/i/item/B09540?utm_source=openai
  6. Antioxidant and oxidative enzymes, genetic variants, and cofactors as prognostic biomarkers of COVID-19 severity and mortality: a systematic review, Frontiers, 2025 -- https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2025.1700263/full?utm_source=openai
  7. Metabolic implications of COVID-19 with a focus on lipid profiles and inflammatory markers, Scientific Reports, 2026 -- https://www.nature.com/articles/s41598-026-37439-5?utm_source=openai
  8. Therapeutics and COVID-19: living guideline, August 2025
  9. Frontiers | Antioxidant and oxidative enzymes, genetic variants, and cofactors as prognostic biomarkers of COVID-19 severity and mortality: a systematic review
  10. Metabolic implications of COVID-19 with a focus on lipid profiles and inflammatory markers | Scientific Reports

Original Source(s)

Changes in Malondialdehyde, 8-iso-prostaglandin F2α, and Lipid Profiles Among COVID-19 Patients: Findings from South-Western Nigeria

  • by Maria Onomhaguan Ebesunun, Donatus Uchechukwu Ozegbe, Promise Chineye Nwaejigh, Bose Etaniamhe Orimadegun, Obiageri Ihuarulam Okeoma

  • January 20, 2026

Related Content

AI Scribes Lag Clinicians on Note Quality

A VHA study across 11 vendors finds AI-generated primary care notes score lower than clinician-written notes, with the largest deficits in thoroughness, organization, and usefulness

Bereavement Tied to Higher Cardiovascular Risk

Acute post-loss period and pandemic conditions each amplified cardiovascular vulnerability in nationwide Swedish cohort study.

Long COVID May Raise Cardiovascular Risk

Population-based cohort shows higher rates of cardiac arrhythmias and coronary artery disease following nonhospitalized infections, with sex-specific differences.