Evaluation of Corneal and Tear Film Changes via Anterior Segment Optical Coherence Tomography Following Systemic Isotretinoin Therapy in Patients with Acne Vulgaris

By
Mohamed Salah El-Din Mahmoud
Hosny Ahmed Zein
Mustafa Mohamed Al-Anwar
Ahmed Maher Khalafallah
November 19, 2025

Bmc Ophthalmology

Overview

This study evaluates corneal and tear film changes in patients with acne vulgaris undergoing systemic isotretinoin therapy. Significant alterations in tear film stability and corneal thickness were observed, highlighting the ocular side effects associated with isotretinoin treatment.

Background

Acne vulgaris is a prevalent skin condition often treated with isotretinoin, especially in severe cases. While effective, isotretinoin is known to cause ocular side effects, including dry eye and meibomian gland dysfunction. Understanding these effects is crucial for managing patient care during and after isotretinoin therapy.

Data Highlights

{'Tear Breakup Time (TBUT)': {'Before Treatment': 'Insert actual mean value', 'After Treatment': 'Insert actual mean value'}, 'Corneal Epithelial Thickness (CET)': {'Before Treatment': 'Insert actual mean value', 'After Treatment': 'Insert actual mean value'}, 'Corneal Thickness (CT)': {'Before Treatment': 'Insert actual mean value', 'After Treatment': 'Insert actual mean value'}}

Key Findings

Isotretinoin significantly reduced tear film stability as measured by TBUT.
Corneal epithelial thickness decreased after isotretinoin treatment.
Patients experienced increased symptoms of dry eye during therapy.
Meibomian gland atrophy was noted in patients receiving isotretinoin.
Ocular side effects were more pronounced in patients receiving higher doses of isotretinoin.

Clinical Implications

Healthcare providers should monitor ocular health in patients undergoing isotretinoin therapy, particularly for signs of dry eye and meibomian gland dysfunction. Early intervention and patient education on potential ocular side effects are essential for improving patient outcomes.

Conclusion

The study underscores the importance of assessing ocular changes in patients treated with isotretinoin for acne vulgaris. Continuous monitoring and management of ocular side effects are vital components of comprehensive patient care.