Early Life Neurodevelopmental Indicators of Attention-Deficit/Hyperactivity Disorder at Age 10: A Prospective Cohort Study - Report - MDSpire

Neurodevelopmental Markers in Early Childhood as Predictors of ADHD at Age 10: Findings from a Longitudinal Cohort Study

  • By

  • Camilla Grube

  • María Hernández-Lorca

  • Julie Rosenberg

  • Kristina Aagaard

  • Michael Widdowson

  • Tingting Wang

  • Nilo Vahman

  • Hanne Lunn Nissen

  • Jens Richardt Møllegaard Jepsen

  • Klaus Bønnelykke

  • Bjørn H. Ebdrup

  • Bo Chawes

  • Rebecca K. Vinding

  • July 20, 2026

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Clinical Report: Neurodevelopmental Markers in Early Childhood as Predictors of ADHD

Overview

This longitudinal cohort study investigates the association between early neurodevelopmental markers and ADHD diagnosis at age 10. Deviations in early neurodevelopment are linked to ADHD traits.

Background

ADHD is a prevalent neurodevelopmental disorder affecting approximately 7% of children, associated with long-term adverse outcomes. Early recognition and intervention are important for diagnosis.

Data Highlights

No numerical data available in the provided source material.

Key Findings

  • ADHD is characterized by symptoms of inattention, hyperactivity, and impulsivity.
  • Early neurodevelopmental markers may help identify children at risk for ADHD.
  • Higher ADHD polygenic risk scores are associated with deviations in early neurodevelopment.
  • ADHD diagnosis often occurs later in childhood, creating a diagnostic gap.
  • Early behavioral and cognitive difficulties are linked to later ADHD outcomes.

Clinical Implications

Identifying early neurodevelopmental markers can aid in the diagnosis of ADHD.

Conclusion

The study emphasizes the role of early neurodevelopmental assessments in predicting ADHD.

Related Resources & Content

  1. Frontiers in Psychiatry, 2026 -- Measurement properties of the Child Behavior Checklist-10: an ultra-brief screening updated in longitudinal cohort
  2. Frontiers in Psychiatry, 2026 -- A connectome-based neural correlate of pediatric ADHD hyperactivity–impulsivity symptoms
  3. BMJ Mental Health, 2026 -- Psychiatric and neurological predictors of early ADHD medication discontinuation across the lifespan: a multinational study
  4. Frontiers in Psychiatry, 2026 -- Adult-diagnosed and childhood-diagnosed attention deficit/hyperactivity disorder: cognitive and environmental contributions to symptom severity across different age of diagnosis
  5. NICE, 2025 -- Recommendations | Attention deficit hyperactivity disorder: diagnosis and management
  6. Early Life Neurodevelopmental Indicators of ADHD and Autism at Age 10: A Prospective Cohort Study, 2026
  7. Integrating genetics, neuroimaging, and environment in ADHD: a systematic umbrella review of meta-analytic evidence, 2026
  8. Recommendations | Attention deficit hyperactivity disorder: diagnosis and management | Guidance | NICE
  9. Early Life Neurodevelopmental Indicators of ADHD and Autism at Age 10: A Prospective Cohort Study
  10. Integrating genetics, neuroimaging, and environment in ADHD: a systematic umbrella review of meta-analytic evidence | Middle East Current Psychiatry | Springer Nature Link

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