Evidence summary on perioperative blood glucose management in liver cancer patients - Report - MDSpire

Overview of Blood Glucose Control During Surgery for Patients with Liver Cancer

  • By

  • Yuxiao Li

  • Ming Pang

  • Caifang Gong

  • Chuan You

  • July 21, 2026

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Clinical Report: Overview of Blood Glucose Control During Surgery for Patients with Liver Cancer

Background

Primary liver cancer is a significant global health concern, with liver resection being a common treatment. Patients often experience stress-induced hyperglycemia due to hepatic insufficiency.

Data Highlights

A total of 14 documents were included in the evidence synthesis, comprising guidelines, systematic reviews, expert consensus statements, and randomized controlled trials relevant to perioperative glycemic management in liver cancer patients.

Key Findings

  • Patients with liver cancer are at high risk for perioperative stress-induced hyperglycemia.
  • Postoperative complications can occur in 18.9% to 53.3% of liver resection patients.
  • Prolonged hyperglycemia impairs liver regeneration and increases the risk of infections and liver failure.
  • Hypoglycemia can be a clinical manifestation of paraneoplastic syndrome in hepatocellular carcinoma.
  • Elevated postoperative fasting blood glucose levels are an independent risk factor for cancer recurrence.

Clinical Implications

Perioperative glycemic management is critical for liver cancer patients to minimize complications.

Related Resources & Content

  1. Management of Hyperglycemia Reduces the Risk of Surgical Site Infections in Non-Diabetic Patients Undergoing Gastrointestinal Surgery, Regardless of Insulin Use
  2. Obesity Surgery — Assessment of Continuous Glucose Monitoring in Bariatric Surgery Patients Undergoing Laparoscopic Sleeve Gastrectomy and Roux-En-Y Gastric Bypass
  3. Management of Diabetes in Surgical Patients: Perioperative Considerations
  4. Impact of Preoperative Oral Carbohydrate Administration on Insulin Sensitivity in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Study
  5. Summary of Revisions: Standards of Care in Diabetes—2026 | Diabetes Care | American Diabetes Association
  6. Impact of differential glycemic management goals in pre-anhepatic and anhepatic phase on early grafted liver function after liver transplantation: An open-label, randomized, controlled study
  7. Preoperative carbohydrate loading reduces length of stay after major elective, non-cardiac surgery when compared to fasting: a systematic review and meta-analysis
  8. Summary of Revisions: Standards of Care in Diabetes—2026 | Diabetes Care | American Diabetes Association
  9. Impact of differential glycemic management goals in pre-anhepatic and anhepatic phase on early grafted liver function after liver transplantation: An open-label, randomized, controlled study - ScienceDirect
  10. Preoperative carbohydrate loading reduces length of stay after major elective, non-cardiac surgery when compared to fasting: a systematic review and meta-analysis | Scientific Reports

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