Association of respiratory viral detection with complex febrile seizures and hospitalisation in children after the COVID-19 pandemic: a retrospective observational study - Report - MDSpire
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Association of respiratory viral detection with complex febrile seizures and hospitalisation in children after the COVID-19 pandemic: a retrospective observational study
Impact of Respiratory Virus Detection on Complex Febrile Seizures in Children
Overview
This study evaluates the associations between respiratory viral detection and clinical outcomes in children with febrile seizures (FS) post-COVID-19.
Background
Febrile seizures are a common pediatric condition, affecting 2%-5% of children aged 6 to 60 months. Understanding the impact of respiratory viruses on febrile seizures is crucial, especially given the changes in viral circulation patterns following the COVID-19 pandemic.
Data Highlights
Variable
Odds Ratio (OR)
95% Confidence Interval (CI)
Parainfluenza Virus (CFS)
0.38
0.16 to 0.89
Seasonal Coronaviruses (CFS)
0.33
0.12 to 0.89
Parainfluenza Virus (Hospitalization)
0.37
0.17 to 0.80
Respiratory Syncytial Virus (Hospitalization)
0.32
0.13 to 0.78
Viral Co-detection (CFS)
0.62
0.44 to 0.88
Viral Co-detection (Hospitalization)
0.66
0.49 to 0.90
Key Findings
Among 558 children studied, 17.0% had complex febrile seizures (CFS).
Detection of parainfluenza virus was associated with lower odds of CFS (adjusted OR 0.38).
Seasonal coronaviruses were also linked to lower odds of CFS (adjusted OR 0.33).
Both parainfluenza virus and respiratory syncytial virus were associated with lower odds of hospitalization.
Viral co-detection occurred in 47.8% of cases, with each additional virus linked to lower odds of CFS and hospitalization.
Clinical Implications
Clinicians should consider the detection of respiratory viruses in the context of the overall clinical presentation of febrile seizures.
Conclusion
The study indicates that certain respiratory viruses and co-detection may be associated with lower clinical severity in febrile seizures.
