Narrative Review of Human Milk Fortifiers for Preterm Infants - Report - MDSpire

Narrative Review of Human Milk Fortifiers for Preterm Infants

  • By

  • Wang, Lu

  • Yin, Dingding

  • Tang, Qing

  • Zhou, Ping

  • June 29, 2026

  • 0 min

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Clinical Report: Nutritional Fortifiers for Human Milk in Preterm Infants

Background

The survival rates of extremely preterm infants have improved due to advancements in neonatal care; however, extrauterine growth restriction remains a significant concern. Human milk alone may not provide sufficient nutrition for very preterm infants.

Data Highlights

No specific numerical data or trial results are provided in the source material.

Key Findings

  • Human milk is the optimal enteral feeding source for preterm infants but may require fortification.
  • Diverse types of human milk fortifiers are employed in various feeding situations for preterm infants.
  • Very preterm infants are at increased risk of infections and post-natal growth failure.
  • Fortification strategies can impact growth and health outcomes in preterm infants.
  • Recent studies have compared the efficacy of different types of milk-derived fortifiers.

Clinical Implications

Healthcare providers should consider the use of nutritional fortifiers to meet the specific dietary needs of very preterm infants. Ongoing research into novel fortifiers may provide additional options for optimizing nutrition in this population.

Conclusion

The supplementation of human milk with nutritional fortifiers is essential for addressing the nutritional deficiencies in preterm infants, and continued research is necessary to refine these practices.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Frontiers in Pediatrics, 2026 -- Extensively hydrolyzed versus intact milk protein formula and risk of necrotizing enterocolitis: a meta-analysis
  3. BMC Pregnancy and Childbirth, 2026 -- The efficacy and the safety of antenatal breastmilk expression on breastfeeding outcomes: a systematic review and meta-analysis
  4. The New Gastroenterologist, 2025 -- Type of Formula Could Increase NEC Risk in Preterm Infants
  5. ESPGHAN Committee on Nutrition, 2022 -- Enteral nutrition in preterm infants: a position paper
  6. American Academy of Pediatrics, 2026 -- Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant: Clinical Report
  7. International Breastfeeding Journal, 2025 -- Impact of three mammalian milk-derived fortifiers on morbidity and mortality in preterm infants: a systematic review and network meta-analysis
  8. Enteral nutrition in preterm infants (2022): a position paper from the ESPGHAN committee on nutrition and invited experts
  9. Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant: Clinical Report | Pediatrics | American Academy of Pediatrics
  10. Impact of three mammalian milk-derived fortifiers on morbidity and mortality in preterm infants: a systematic review and network meta-analysis | International Breastfeeding Journal | Springer Nature Link

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