Toward Participatory Precision Health With Co-Designed Recommendations: Systematic Review of Just-in-Time Adaptive Interventions in Adolescents and Young Adults - Report - MDSpire

Toward Participatory Precision Health With Co-Designed Recommendations: Systematic Review of Just-in-Time Adaptive Interventions in Adolescents and Young Adults

  • By

  • Kathleen W Guan

  • Mohammed Amara

  • Viviana Cortiana

  • Imran Khan

  • Sıla Gürbüz

  • Carmine Iorio

  • Rayyan Ali

  • Christopher Adlung

  • Crystal R Smit

  • Annabel Vreeker

  • Eva Thalassinou

  • Eeske van Roekel

  • Loes Keijsers

  • Mark de Reuver

  • Caroline A Figueroa

  • May 21, 2026

  • 0 min

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Advancing Collaborative Precision Health Through Co-Developed Recommendations

Overview

This systematic review evaluates just-in-time adaptive interventions (JITAIs) aimed at adolescents and young adults (AYAs), highlighting their potential to deliver tailored health support. The findings underscore the importance of precision health strategies in addressing the dynamic health needs of AYAs during their transition to adulthood.

Background

Adolescence is a critical period for health interventions, as behaviors established during this time can lead to chronic diseases later in life. The transition to adulthood involves complex biological, psychological, and social changes, making targeted interventions essential. Precision health approaches, particularly JITAIs, offer a promising method to provide personalized support that adapts to the evolving needs of AYAs.

Data Highlights

No specific numerical data or trial results were provided in the source material.

Key Findings

  • JITAIs utilize ongoing data from mobile sensing technology to deliver contextually relevant support.
  • Most prior analyses of JITAIs have focused on older adults or specific health conditions, indicating a gap in understanding their application for AYAs.
  • Mobile health technologies can enhance engagement by delivering tailored health interventions to AYAs.
  • Behavioral patterns in AYAs are influenced by fluctuating contexts and interactions, necessitating dynamic intervention strategies.
  • Challenges exist in maintaining engagement with mHealth interventions when content does not adapt to changing circumstances.

Clinical Implications

Healthcare providers should consider the unique developmental needs of AYAs when designing interventions. Implementing JITAIs may enhance the effectiveness of health support by ensuring that interventions are responsive to the individual circumstances of adolescents and young adults.

Conclusion

The review highlights the potential of JITAIs to improve health outcomes for AYAs by providing timely and personalized support. Further research is needed to explore their effectiveness in diverse contexts.

Related Resources & Content

  1. npj Digital Medicine, 2026 -- Assessing Youth Mental Health Needs Through an Adaptive Digital Tool: Findings from a Cross-Sectional Analysis
  2. npj Digital Medicine, 2025 -- Systematic review of dynamically tailored eHealth interventions targeting physical activity and healthy diet in chronic disease
  3. Journal of Medical Internet Research (JMIR), 2026 -- Current Practices and a Novel Operational Framework for Planning Research on Digital Health Promotion Interventions From Development to Implementation: Scoping Review
  4. Clinical Practice Guideline: Assessment and Treatment of Adolescents and Young Adults With Substance Use Disorders and Problematic Substance Use - ScienceDirect
  5. Effectiveness of just-in-time adaptive interventions for improving mental health and psychological well-being: a systematic review and meta-analysis | BMJ Mental Health
  6. npj Digital Medicine — Active components in digital health interventions for sleep among adolescents: a systematic review and meta-analysis of randomized controlled trials
  7. Guidances with Digital Health Content | FDA
  8. Clinical Practice Guideline: Assessment and Treatment of Adolescents and Young Adults With Substance Use Disorders and Problematic Substance Use (Excluding Tobacco) - ScienceDirect
  9. Effectiveness of just-in-time adaptive interventions for improving mental health and psychological well-being: a systematic review and meta-analysis | BMJ Mental Health
  10. Just-in-Time Adaptive Interventions for Adolescent and Young Adult Substance Use: A Systematic Review - ScienceDirect
  11. Effectiveness of a Mobile Phone-Delivered Multiple Health Behavior Change Intervention (LIFE4YOUth) in Adolescents: Randomized Controlled Trial - PubMed
  12. A just‐in‐time adaptive personalized mobile app intervention produces limited short‐term reductions in heavy episodic drinking frequency in college students: A randomized control trial during the COVID‐19 pandemic | CoLab
  13. Towards Participatory Precision Health: Systematic Review and Co-designed Guidelines For Adolescent Just-in-time Adaptive Interventions | medRxiv

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