Association of triglyceride–glucose and obesity-derived indices with the risk of aortic stenosis among individuals in cardiovascular–kidney–metabolic syndrome stages 0–3: a prospective cohort study from the UK Biobank - Report - MDSpire
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Association of triglyceride–glucose and obesity-derived indices with the risk of aortic stenosis among individuals in cardiovascular–kidney–metabolic syndrome stages 0–3: a prospective cohort study from the UK Biobank
Linking triglyceride–glucose levels and obesity-related metrics to aortic stenosis risk
Overview
This study investigates the association between triglyceride-glucose (TyG) indices and aortic stenosis (AS) risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3. Findings indicate that higher TyG-related indices correlate with increased AS risk.
Background
Cardiovascular-kidney-metabolic (CKM) syndrome represents a critical intersection of metabolic dysfunction, kidney injury, and cardiovascular abnormalities. Understanding the relationship between insulin resistance, as indicated by TyG indices, and AS risk is essential.
Data Highlights
TyG Index
Increased AS Risk
1-SD Increment
8-24%
Highest Tertile vs. Lowest Tertile
1.13-1.77-fold
SBP Mediation
12.1-18.1%
TyG-WHtR C-index
0.806
TyG-WHtR NRI
0.308
Key Findings
3,326 cases of aortic stenosis occurred during 15.25 years of follow-up.
Each 1-SD increment in TyG-related indices was associated with an 8-24% increased risk of AS.
The highest tertile of TyG indices showed a 1.13-1.77-fold increased risk of AS compared to the lowest tertile.
All TyG-related indices exhibited linear dose-response relationships with AS risk.
Systolic blood pressure mediated 12.1-18.1% of the associations between TyG indices and AS risk.
TyG-WHtR provided the greatest predictive improvement for AS risk assessment.
Clinical Implications
TyG-related indices may serve as tools for risk assessment in patients with CKM syndrome.
Conclusion
TyG-related indices are associated with aortic stenosis risk in individuals with CKM syndrome stages 0-3.
